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博士&硕士生导师

吴选俊

日期:2021-07-28点击:


吴选俊 教授

博士,博士生导师,山东大学齐鲁青年学者

通讯地址: 山东省青岛市即墨滨海公路72号山东大学青岛校区K6-206

手机: 19155140390

办公室电话:(0532)-58631426

邮箱: xuanjun@sdu.edu.cn


教育经历

2010.9-2015.6 厦门大学化学化工学院化学生物学系,理学博士,导师: 韩守法教授

2005.9-2009.7 安徽农业大学生物技术专业,理学学士


工作经历

2019.6-  山东大学国家糖工程技术研究中心,山东大学齐鲁青年学者/教授

2015.7-2019.5 美国密歇根州立大学化学系,博士后,导师: 黄雪飞教授


研究方向

1. 2019新冠病毒疫苗的研究

2. 神经节苷脂抗癌疫苗的研究与开发

3. MUC1抗癌疫苗的研究与开发

4. 多糖疫苗的研究与开发


奖励与荣誉

1. 2012,教育部博士学术新人奖,教育部

2. 2014,博士研究生国家奖学金,教育部

3. 2018,福建医学科技奖,二等奖,福建省

4. 2019,厦门市科学技术进步奖,二等奖,厦门市

5. 2019,福建省科学技术进步奖,二等奖,福建省


科研项目

1. 国家自然科学基金青年科学基金,2021-012023-12,在研,主持

2. 山东省自然科学基金青年基金,2021-012023-12,在研,主持

3. 江苏省自然科学基金青年基金,2020-072023-06,在研,主持

4. 山东大学微生物技术国家重点实验室开放课题基金,2020-072021-07,结题,主持

5. 山东大学齐鲁青年学者基金,2019-052024-05,在研,主持

6. 美国国家癌症研究所,研究计划基金,2018-012022-12250万美元,在研,参加

代表性论文

入职糖中心后:

1. X Wu, J Ye, A T. DeLaitsch, Z Rashidijahanabad, S Lang, T Kakeshpour, Y Zhao, S R, P V Saavedra, V Yuzbasiyan-Gurkan, H Cao,* J Gildersleeve,* and X Huang*. Chemoenzymatic Synthesis of 9NHAc-GD2 Antigen to Overcome Hydrolytic Instability of O-Acetylated-GD2 for Anticancer Conjugate Vaccine Development, Angew. Chem. Int. Ed. 2021, DOI: 10.1002/anie.202108610. (IF= 15.336)

2. Y Gao, Q Zhao, H Dong, M Xiao, X Huang, X Wu*, Developing acid-responsive glyco-nanoplatform based vaccines for enhanced cytotoxic T-lymphocyte responses against cancer and SARS-CoV-2, Adv. Funct. Mater., 2021, DOI: 10.1002/adfm.202105059. (IF= 18.808)

3. Y Gao, Q Zhao, M Xiao, X Huang, X Wu*, A versatile photothermal vaccine based on acid-responsive glyco-nanoplatform for synergistic therapy of cancer, Biomaterials, 2021, 273, 120792. (IF= 12.479)

4. Q Zhao, Y Gao, M Xiao, X Huang, X Wu*, Synthesis and immunological evaluation of synthetic peptide based anti-SARS-CoV-2 vaccine candidates, Chem. Commun., 2021, 57, 14741477. (IF = 6.222)

5. X Wu, H McFall-Boegeman, Z Rashidijahanabad, K Liu, C Pett, J Yu, M Schorlemer, S Ramadan, S Behren, U Westerlind and X Huang, Synthesis and Immunological Evaluation of the Unnatural β-linked Mucin-1 Thomsen-Friedenreich Conjugate, Org. Biomol. Chem., 2021, 19, 2448–2455. (IF = 3.876)

6. S Lang, Z Tan, X Wu, X Huang, Synthesis of Carboxy-Dimethylmaleic Amide Linked Polymer Conjugate Based Ultra-pH-sensitive Nanoparticles for Enhanced Antitumor Immunotherapy, ACS Macro Letters, 2020, 9, 16931699. (IF = 6.903)

7. X Wang, S Lang, Y Tian, J Zhang, X Yan, Z Fang, Z Fang, J Weng, N Lu, X Wu, T Li, H Cao, Z Li*, and X Huang*. Glycoengineering of natural killer cells with CD22 ligands for enhanced anticancer immunotherapy. ACS Central Science. 2020, 6, 382389. (IF = 14.553)

8. X Wu, C McKay, C Pett, J Yu, M Schorlemer, S Ramadan, S Lang, U Westerlind, M. Finn, and X Huang*. Synthesis and immunological evaluation of disaccharide bearing MUC-1 glycopeptide conjugates with virus-like particles. ACS Chem. Biol. 2019, 14, 21762184. (IF = 5.100)


入职糖中心前:

9. X Wu, Z Yin, C McKay, C Pett, J Yu, M Schorlemer, T Gohl, S Sungsuwan, S Ramadan, C Baniel, Anthony, R Das, U Westerlind, M. Finn, and X Huang*. Protective epitope discovery and the design of MUC1 based vaccine for effective tumor protections in immunotolerant mice. J. Am. Chem. Soc., 2018, 140, 1659616609. (IF = 15.419)

10. Z Yin†, X Wu†, K Kaczanowska, S Sungsuwan, Aragones, C Pett, J Yu, C Baniel, U Westerlind, M Finn, and X Huang*. Anti-tumor humoral and T cell responses by mucin-1 conjugates of bacteriophage Qb in wildtype mice. ACS Chem. Biol. 2018, 13, 16681676. (†, contributed equally) (IF = 5.100)

11. B Lin†, X Wu†, H Zhao, Y Tian, J Han, J Liu, S Han*. Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface. Chem. Sci., 2016, 7, 37373741. (†, contributed equally) (IF = 9.825)

12. X Wu, B Lin, M Yu, L Yang, J Han, S Han*. A carbohydrate-grafted nanovesicle with activatable optical and acoustic contrasts for dual modality high performance tumor imaging. Chem. Sci. 2015, 6, 20022009. (IF = 9.825)

13. X Wu, M Yu, B Lin, H Xing, J Han, S Han*. A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation. Chem. Sci. 2015. 6, 789803. (IF = 9.825)

14. X Wu, Y Tian, M Yu, J Han, S Han*. A targetable acid-responsive micellar system for signal activation based high performance surgical resolution of tumors. Biomater. Sci. 2014, 2, 972979. (IF = 6.843)

15. X Wu, Y Tian, M Yu, B Lin, J Han, S Han*. A fluorescently labelled sialic acid for high performance intraoperative tumor detection. Biomater. Sci. 2014, 2, 11201127. (IF = 6.843)

16. X Wu, J Shi, L Yang, J Han, S Han*. A near-infrared fluorescence dye for sensitive detection of hydrogen sulfide in serum. Bioorg Med Chem Lett. 2014, 24, 314316. (IF = 2.448)

17. X Wu, Z Li, L Yang, J Han, S Han*. A self-referenced nanodosimeter for reaction based ratiometric imaging of hypochlorous acid in living cells. Chem. Sci. 2013, 4, 460467. (IF = 9.825)

18. X Wu, Y Song, J Han, L Yang, S Han*. Traceless protein delivery with an efficient recyclable nanocarrier. Biomater. Sci. 2013, 1, 918923. (IF = 6.843)

19. Z Wu†, X Wu†, Z Li, Y Yang, J Han, S Han*. Benzothiazoline based chemodosimeters for fluorogenic detection of hypochlorous acid. Bioorg Med Chem Lett 2013, 23, 43544357. (†, contributed equally) (IF = 2.448)

20. X Wu, S Wu, L Yang, J Han, S Han*. Cytosolic delivery of proteins mediated by aldehyde-displaying silica nanoparticles with pH-responsive characteristics. J. Mater. Chem. 2012, 22, 1712117127. (IF = 6.626)

21. X Wu, Z Wu, Y Yang, S Han*. A highly sensitive fluorogenicchemodosimeter for rapid visual detection of phosgene. Chem. Commun. 2012, 48, 18951897. (IF = 6.222)

22. X Wu, Z Wu, S Han*. Chromogenic and fluorogenic detection of a nerve agent simulant with a rhodamine-deoxylactam based sensor. Chem. Commun. 2011, 47, 1146811470. (IF = 6.222)


获得国家发明专利

1. ZL 2013 1 0287924. X,磷酸吡哆醛功能化磷酸钙纳米颗粒及其制备方法与应用,发明人:韩守法,吴选俊

2. ZL201410015353.9,罗丹明功能化的聚(苯乙烯-交替半乳糖基马来酸)及其合成方法与应用,发明人:韩守法,吴选俊

3. ZL201410069518.0,一种荧光素标记的唾液酸试剂及其制备方法与应用,发明人:韩守法,吴选俊, 田云鹏

4. ZL201510474118.2,一种抗原连接的唾液酸及其应用,发明人:韩守法,刘剑,吴选俊, 林碧娟


本课题组在生物化学与分子生物学和生物医药专业均招收硕士、博士研究生。欢迎有兴趣的考生报考!


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