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博士&硕士生导师

肖 敏

日期:2021-07-28点击:

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肖敏 教授

博士生导师

联系方式:0532-58631402

E-mail : minxiao@sdu.edu.cn

国家糖工程技术研究中心副主任

山东省青岛市即墨区滨海路72号青岛校区淦昌苑F楼234室

教育背景:

博士 1996.9-2000.6 山东大学 微生物学

硕士 1985.9-1988.6 山东大学 微生物学

本科 1981.9-1985.9 山东大学 微生物学

工作经历:

2001-今 教授,博士生导师, 山东大学 微生物技术国家重点实验室&国家糖工程技术研究中心

1996-2000 副教授, 山东大学 微生物技术国家重点实验室

1988-1995 助教及讲师, 山东大学微生物系

2003 美国Wayne State Univ访问学者

1997-1998 日本京都大学(Kyoto Univ)UNESCO微生物学高级研修

科研方向:

生物催化与生物合成,重点开展酶催化的糖基化作用研究。

主持课题:

1. 国家重点研发计划“合成生物学”重点专项项目“基于成药性特征的微生物天然产物合成生物学创制”课题2“以增加水溶性为导向的合成生物学创制”(2018YFA0902002)

2. 国家自然基金项目“新的具有转糖基活性的唾液酸苷酶的基因发掘、分子改造及其催化分子机制研究”(31872626)

3. 国家自然基金项目“分子进化α-L-鼠李糖苷酶及酶法合成抗肿瘤药物的鼠李糖苷研究”(31670062)

4. 国家重点基础研究发展计划(973计划)“肿瘤的糖化学生物学前沿研究”课题2糖链探针的生物合成研究(2012CB822102)

5. 国家自然基金项目“米曲霉降解尼古丁的代谢途径、酶及其基因研究”(31170054)

6. 国家自然基金项目“分子改造Levan蔗糖酶拓展转糖基底物特异性研究”(31070064)

7. 国家自然基金项目“固氮红细菌类胡萝卜素代谢途径及其八氢番茄红素脱氢酶催化机制研究”(30970028)

8. 国家自然基金项目“具有转糖基活性的-半乳糖苷酶的分子改造”(30770065).

9. 国家863项目“分子改造糖苷酶转糖苷法制备低聚半乳糖技术”(2006AA10Z338)

10. 国家自然科学基金项目 “双歧杆菌-D-半乳糖苷酶转糖基作用的区域选择性研究”(30170008)

部分发表论文 (2015-2020)

1. Peng Liu, Huaqin Zhang, Yuying Wang, Xiaodi Chen, Lan Jin, Li Xu*,Min Xiao*. Screening and characterization of an α-L-fucosidase fromBacteroides fragilisNCTC9343 for synthesis of fucosyl-N-acetylglucosamine disaccharides. Appl Microbiol Appl Microbiol Biotechnol. 2020, 104: 7827-7840

2. Yinping Li, Weiying Hong, Henan Zhang, Tian Tian Zhang, Zhiyong Chen, Shiling Yuan, Peng Peng*,Min Xiao*,Li Xu*. Photothermally triggered cytosolic drug delivery of glucose functionalized polydopamine nanoparticles in response to tumor microenvironment for the GLUT1-targeting chemo-phototherapy. J Control Release. 2020, 317: 232-245.

3. Xiaodi Chen, Lan Jin, Xukai Jiang, Longcheng Guo, Guofeng Gu , Li Xu 1, Lili Lu, Fengshan Wang,Min Xiao*. Converting a β-N-acetylhexosaminidase into two trans-β-N-acetylhexosaminidases by domain-targeted mutagenesis. Appl Microbiol Biotechnol. 2020, 104(2): 661-673.

4. Li Xu, Xiaohong Liu , Yinping Li , Zhenhao Yin, Lan Jin, Lili Lu, Jingyao Qu,Min Xiao*. Enzymatic rhamnosylation of anticancer drugs by an α-L-rhamnosidase fromAlternariasp. L1 for cancer-targeting and enzyme-activated prodrug therapy. Appl Microbiol Biotechnol. 2019, 103(19): 7997-8008

5. Ke Wang, Tingting Qi, Longcheng Guo, Zhongxuan Ma, Guofeng Gu,Min Xiao*, Lili Lu*. Enzymatic Glucosylation of Salidroside from Starch by α-Amylase. J Agric Food Chem. 2019, 67, 2012-2019

6. Tiantian Zhang, Yinping Li, Weiying Hong, Zhiyong Chen, Peng Peng, Shiling Yuan, Jingyao Qu,Min Xiao*, Li Xu*. Glucose oxidase and polydopamine functionalized iron oxide nanoparticles: combination of the photothermal effect and reactive oxygen species generation for dual-modality selective cancer therapy. J Mater Chem B. 2019, 7:2190-2200.

7. Chunjuan He, Yougui Huang, Peng Liu, Jianhuan Wei, Yirui Yang, Li Xu*,Min Xiao*. Transcriptome analysis of genes and metabolic pathways associated with nicotine degradation inAspergillus oryzae112822. BMC genomics. 2019, 20: 86. doi:10.1186/s12864-019-5446-2

8. Longcheng Guo, Xiaodi Chen, Li Xu,Min Xiao*,Lili Lu*. Enzymatic Synthesis of 6’α-Sialyllactose, a Dominant Sialylated Human Milk Oligosaccharide, by a Novel exo-α-Sialidase fromBacteroides fragilisNCTC9343. Appl Environ Microbiol. 2018, 84(13):e00071-18

9. Chunjuan He, Yirui Yang, Renfei Zhao, Jingyao Qu, Lan Jin, Lili Lu, Li Xu*,Min Xiao*.Rational designed mutagenesis of levansucrase fromBacillus licheniformis8-37-0-1 for product specificity study. Appl Microbiol Biotechnol. 2018, 102(7):3217-3228

10. Tingting Qi, Guofeng Gu, Li Xu,Min Xiao*, Lili Lu*. Efficient synthesis of tyrosol galactosides by the β-galactosidase fromEnterobacter cloacaeB5. Appl Microbiol Biotechnol. 2017, 101(12):4995-5003.

11. Xiaodi Chen, Li Xu, Lan Jin, Bin Sun, Guofeng Gu, Lili Lu*,Min Xiao*.Efficient and regioselective synthesis of β-GalNAc/GlcNAc-lactose by a bifunctional transglycosylating β-N-acetylhexosaminidase from Bifidobacterium bifidum. Appl Environ Microbiol. 2016, 82(18):5642-5652.

12. Li Xu, Xiaohong Liu, Zhenhao Yin, Qian Liu, Lili Lu,Min Xiao*.Site-directed mutagenesis of α-L-rhamnosidase from Alternaria sp. L1 to enhance synthesis yield of reverse hydrolysis based on rational design. Appl Microbiol Biotechnol. 2016, 100(24):10385-10394.

13. Wei Gong,Li Xu,Guofeng Gu,Lili Lu,Min Xiao*. Efficient and regioselective synthesis of globotriose by a novel α-galactosidase from Bacteroides fragilis. Appl Microbiol Biotechnol 2016,100: 6693–6702.

14. Lijuan Xu, Tingting Qi, Li Xu, Lili Lu*,Min Xiao*. Recent progress in the enzymatic glycosylation of phenolic compounds. Journal of Carbohydrate Chemistry. 2016, 35(1):1-23.

15. Jie Zhang, Lili Lu, Li Lu, Yang Zhao, Liping Kang, Xu Pang, Jingyuan Liu, Tengchuan Jiang,Min Xiao*,Baiping Ma*. Galactosylation of steroidal saponins byβ-galactosidase from Lactobacillus bulgaricus L3. Glycoconj J. Glycoconj J. 2016, 33(1):53-62.

16. Shuquan Fan, Huaqin Zhang, Xiaodi Chen, Lili Lu, Li Xu,Min Xiao*. Cloning, characterization, and production of three α-L-fucosidases from Clostridium perfringens ATCC 13124. J Basic Microbiol. 2015, 55(4), 347-357.

17. Lili Lu, Qian Liu, Lan Jan, Zhenghao Yin, Li Xu,Min Xiao*. Enzymatic synthesis of rhamnose containing chemicals by reverse hydrolysis. PLoS One. 2015, 10(10):e0140531.

18. Lili Lu, Yuchuan Guo, Lijuan Xu, Tingting Qi, Lan Jin, Li Xu,Min Xiao*. Galactosylation of caffeic acid by an engineeredβ-galactosidase. Drug Discoveries & Therapeutics. 2015; 9(2):123-128.

19. Lili Lu, Lijuan Xu, Yuchuan Guo, Dayu Zhang, Tingting Qi, Lan Jin, Guofeng Gu, Li Xu,Min Xiao*. Glycosylation of Phenolic Compounds by the Site-Mutated β-Galactosidase from Lactobacillus bulgaricus L3. PLoS ONE. 2015, 10(3): e0121445.

20. Lili Zhang, Lili Lu, Shuquan Fan, Lan Jin, Guofeng Gu, Li Xu,Min Xiao*. One-step synthesis of α-Gal epitope and globotriose derivatives by an engineered α-galactosidase. RSC Advances, 2015, 5, 22361 – 22364.

授权发明专利:

ZL 2005 1 0044096.2;ZL 2005 1 0044097.7;ZL 2005 1 0044897.9;

ZL 2005 1 0044095.8;ZL 2005 1 0044898.3;ZL 2007 1 0015198.0;

ZL 2007 1 0116242.7;ZL 2008 1 0014906.3;ZL 2008 1 0157830.X;

ZL 2008 1 0139284.7;ZL 2010 1 0173646.1;ZL 2010 1 0220786.X;

ZL 2010 1 0173582.5;ZL 2010 1 0216912.4;ZL 2011 1 0119959.3;

ZL 2011 1 0190899.4;ZL 2011 1 0190960.5;ZL 2011 1 0190940.8;

ZL 2011 1 0002979.2;ZL 2012 1 0156757.0;ZL 2013 1 0257432.6;

ZL 2013 1 0121813.1;ZL 2013 1 0256580.6;ZL 2013 1 0257340.8;

ZL 2013 1 0256401.9;ZL 2013 1 0257383.6;ZL 2013 1 0255797.5;

ZL 2014.1.0177678.7;ZL 2015 1 0496988.X;ZL 2015 1 0497366.9;

ZL 2015 1 0746918.5;ZL 2016 1 0979793.5;ZL 2017 1 0128644.2.

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