当前位置: 首页 > 人才培养 > 导师信息 > 硕士生导师 > 正文

人才培养

硕士生导师

靳 岚

日期:2021-07-28点击:

靳岚,女,博士,副教授,硕士生导师

山东省青岛市即墨区,滨海路72号,山东大学青岛校区K6208室,邮编: 266237

电话:0532-58631418

E-maillanjin@sdu.edu.cn

教育经历:

1999.08 – 2003.07 辽宁大学化学院,应用化学专业,本科,获理学学士学位;

2003.10 – 2007.06 英国University of Edinburgh化学院,生物物理化学专业,获理学博士学位。

工作经历:

2007.06 – 2008.07 英国University of Edinburgh化学院,生物核磁组,博士后研究员;英国BBSRC方法学改进项目,NMR定量研究糖与蛋白质相互作用;

20088月入职山东大学国家糖工程技术研究中心,副教授,硕士生导师。主要从事生物核磁共振波谱方法、低分子肝素药物结构验证、糖与蛋白质相互作用的构效关系研究。主持国家及省部级科研项目及企业委托研发项目多项,已在Analytical ChemistryCarbohydrate Polymers等杂质发表SCI收录论文30余篇。

主要研究方向:

1NMR表征寡糖分子空间结构;

2、寡糖与蛋白质的相互作用及构效关系研究;

3、糖胺聚糖类药物、多肽类药物的结构相似性评价。

主持项目:

1、 教育部博士点新教师基金(20100131120070透明质酸寡糖逆转肿瘤细胞多药耐药作用的机制研究 2011年;

2、 山东省自然科学基金面上项目(ZR2011CM038肝素寡糖与β淀粉样蛋白相互作用的核磁共振研究2011年;

3、 北京分子科学国家实验室开放课题肝素寡糖抑制淀粉样蛋白细胞毒性的分子机制研究2013年;

4、 国家自然科学基金(青年科学基金项目21302113肝素寡糖抑制淀粉样蛋白细胞毒性的构效关系研究2014

另有多家生物医药企业委托横向课题10余项。

通讯作者论文:

1. Anran Sheng, Qingqing Chen, Mengqi Yu, Ruiqi Xiao, Tianji Zhang, Zhiyu Wang, Robert J. Linhardt, Xiaojun Sun*, Lan Jin*, and Lianli Chi*Coupling Liquid Chromatography and Tandem Mass Spectrometry to Electrophoresis for In-Depth Analysis of Glycosaminoglycan Drugs: Heparin and the Multicomponent Sulodexide, Analitical Chemistry, 2021, 931433-1442.

2. Changkai Bu and Lan Jin*, NMR Characterization of the Interactions Between Glycosaminoglycans and Proteins, Frontiers in Molecular Bioscience, 2021, 8: 646808.

3. Kening Xu, Lan Jin*. The role of heparin/heparan sulphate in the IFN-gamma-led Arena, Biochimie, 2020, 170(1): 1-9.

4. Shaoshuai Xie, Yudong Guan, Peipei Zhu, Fei Li, Mengqi Yu, Robert J. Linhardt, Lianli Chi*, Lan Jin*. Preparation of low molecular weight heparins from bovine and ovine heparins using nitrous acid degradation, Carbohydrate Polymers, 2018, 197: 83-91.

5. Peipei Zhu, Lan Jin*. Cell penetrating peptides: a promising tool for the cellular uptake of macromolecular drugs, Current Protein & Peptide Science, 2018, 19(2): 211-220.

6. Guangxiu Deng, Lan Jin*. The effects of vasoactive intestinal peptide in neurodegenerative disorders, Neurological Research, 2017, 39(1): 65-72.

第一作者论文:

1. Lan Jin, Miloš Hricovíni, Jon A Deakin, Malcolm Lyon, Dušan Uhrín. Residual dipolar coupling investigation of a heparin tetrasaccharide confirms the limited effect of flexibility of the iduronic acid on the molecular shape of heparin, Glycobiology, 2009, 19: 1185-1196.

2. Lan Jin, Katalin E. Kövér, Marc R. Lenoir, Dušan Uhrín. 1H-detected IPAP DEPT-INADEQUATE and IPAP RINEPT-INADEQUATE for the measurement of long-range carbon-carbon coupling constants, Journal of Magnetic Resonance, 2008, 190: 171-182.

3. Lan Jin, Dušan Uhrín. 13C-detected IPAP-INADEQUATE for simultaneous measurement of one-bond and long-range scalar or residual dipolar coupling constants, Magnetic Resonance in Chemistry, 2007, 45: 628-633.

4. Lan Jin, Tran N. Pham, Dušan Uhrín. Measurement of 1H-1H Residual Dipolar Coupling Constants for Structural Studies of Medium Size Molecules, ChemPhysChem, 2007, 8: 1228-1235.

5. Lan Jin, Perdita E. Barran, Jon A. Deakin, Malcolm Lyon, Dušan Uhrín. Conformation of glycosaminoglycans by ion mobility mass spectrometry and molecular modelling, PhysChemChemPhys, 2005, 7: 3464-3471.

合作论文:

1. Yudong Guan, Xiaohui Xu, Xinyue Liu, Anran Sheng, Lan Jin, Robert J. Linhardt, Lianli Chi. Comparison of Low-Molecular-Weight Heparins Prepared from Bovine Lung Heparin and Porcine Intestine Heparin, Journal of Pharmaceutical Sciences, 2016, 105: 1843-1850.

2. Jiajun Xue, Lan Jin, Xinke Zhang, Fengshan Wang, Peixue Ling, Juzheng Sheng. Impact of donor binding on polymerization catalyzed by KfoC by regulating the affinity of enzyme for acceptor, Biochimica et Biophysica Acta (BBA) - General Subjects, 2016, 1860(4): 844-855.

3. Yan Zhang, Caicai Meng, Lan Jin, Xi Chen, Fengshan Wang, Hongzhi Cao. Chemoenzymatic synthesis of α-dystroglycan core M1 O-mannose glycans, Chemical Communications, 2015, 51, 11654-11657.

4. Xin Meng, Wenlong Yao, Jiansong Cheng, Xu Zhang, Lan Jin, Hai Yu, Xi Chen, Fengshan Wang, Hongzhi Cao. Regioselective chemoenzymatic synthesis of ganglioside disialyl-tetrasaccharide epitopes, Journal of the American Chemical Society, 2014, 136: 5205-5208.

5. Zhangjie Wang, Daoyuan Li, Xiaojun Sun, Xue Bai, Lan Jin, Lianli Chi. Liquid chromatography-diode array detection-mass spectrometry for compositional analysis of low molecular weight heparins, Analytical Biochemistry, 2014, 451: 35-41.

6. Daoyuan Li, Lequan Chi, Lan Jin, Xiaohui Xu, Xuzhao Du, Shengli Ji, Lianli Chi. Mapping of low molecular weight heparins using reversed phase ion pair liquid chromatography-mass spectrometry, Carbohydrate Polymers, 2014, 99: 339-344.


上一篇:陈宗刚

下一篇:蔡 峰