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人才培养

硕士生导师

高 健

日期:2021-07-28点击:

高健 研究员

博士,硕士生导师

山东省青岛市滨海路72号

山东大学青岛校区淦昌苑F-128室

电话: 0532-58631410

E-mail:jgao@sdu.edu.cn

教育经历:

2006.09-2012.06,山东大学,药学院,医学博士,导师:娄红祥教授

2001.09-2006.06,泰山医学院,药学系,医学学士

科研与学术工作经历:

2016.04-至今,山东大学,国家糖工程技术研究中心,研究员

2012.06-2016.04,美国韦恩州立大学,化学系,博士后,合作导师:郭忠武教授

研究方向:

1.具有重要生物活性的复杂糖类分子的合成及药物开发

2.糖化学合成方法学研究

3.新型抗细菌糖缀合物疫苗研究

主持科研项目:

1.国家自然科学基金青年基金项目(21702124)

2.山东省自然科学基金面上项目(ZR2017MB013)

3.山东省重点研发计划项目(2018GSF118120)

4.山东大学青年学者未来计划项目(2018WLJH41)

发表论文(通讯及第一作者):

1. H. Zhang, L. Shao, X. Wang, Y. Zhang, Z. Guo,*J. Gao.* One-pot synthesis of the repeating unit of type VII group BStreptococcuscapsular polysaccharide and the dimer.Org. Lett.2019, 21, 2374-2377.

2. Y. Zhang, S. Zhou, X. Wang, H. Zhang, Z. Guo,*J. Gao.* A new method for α-specific glucosylation and its application to the one-pot synthesis of a branched α-glucan.Org. Chem. Front.2019, 6, 762-772.

3. H. Zhang, S. Zhou, Y. Zhao,J. Gao.* Chemical synthesis of the dimeric repeating unit of type Ia group BStreptococcuscapsular polysaccharide.Org. Biomol. Chem.2019, 17, 5839-5848.

4. L. Shao, H. Zhang, Y. Li, G. Gu, F. Cai, Z. Guo,*J. Gao.*Chemical synthesis of the repeating unit of type II group BStreptococcuscapsular polysaccharide.J. Org. Chem.2018, 83, 5920-5930.

5.J. Gao, Z. Guo. Progress in the synthesis and biological evaluation of lipid A and its derivatives.Med. Res. Rev.2018, 38, 556-601.

6.J. Gao, Z. Guo. Synthetic studies of GPI-anchored peptides, glycopeptides, and proteins. RSCChemical Biology of Glycoproteins,2017, 253-281.

7.J. Gao, Z. Zhou, J. Guo, Z. Guo. Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins.Chem. Commun.2017, 53, 6227-6230.

8.J. Gao, Z. Guo. Chemical synthesis of the repeating unit of type V group BStreptococcuscapsular polysaccharide.Org. Lett.2016, 18, 5552-5555.

9. L. Lu,#J. Gao,#Z. Guo. Labeling cell surface GPIs and GPI-anchored proteins through cell metabolic engineering with artificial inositol derivatives.Angew. Chem. Int. Ed.2015, 54, 9679-9682.

10.J. Gao, G. Liao, L. Wang, Z. Guo.Synthesis of a miniature lipoarabinomannan.Org. Lett.2014, 16, 988-991.

11. X. Zan,#J. Gao,#G. Gu, S. Liu, B. Sun, L. Liu, H. Lou. Synthesis and cytotoxic effect of pseudodiosgenyl saponins with thio-ring F.Bioorg. Med. Chem. Lett.2014, 24, 1600-1604.

12.J. Gao, Z. Guo. Synthesis of a tristearoyl lipomannan via preactivation-based iterative glycosylation.J. Org. Chem.2013, 78, 12717-12725.

13.J. Gao, X. Li, G. Gu, S. Liu, M. Cui, H. Lou. Facile synthesis of triterpenoid saponins bearingβ-Glu/Gal-(1→3)-β-GluA methyl ester and their cytotoxic activities.Bioorg. Med. Chem. Lett.2012, 22, 2396-2400.

14.J. Gao, X. Li, G. Gu, B. Sun, M. Cui, M. Ji, H. Lou. Efficient synthesis of trisaccharide saponins and their tumor cell killing effects through oncotic necrosis.Bioorg. Med. Chem. Lett.2011, 21, 622-627.

15. Y. Wang,#J. Gao,#G. Gu, G. Li, C. Cui, B. Sun, H. Lou. In situ RBL receptor visualization and its mediated anticancer activity for solasodine rhamnosides.ChemBioChem.2011, 12, 2418-2420.

16. C. Duan,#J. Gao,#D. Zhang, L. Jia, Y. Liu, D. Zheng, G. Liu, X. Tian, F. Wang, Q. Zhang. Galactose-decorated pH-responsive nanogels for hepatoma-targeted delivery of oridonin.Biomacromolecules.2011, 12, 4335-4343.

17.J. Gao, X. Li, B. Lv, B. Sun, C. Zhu, H. Lou. LC-DAD/MS/MS detection of macrocyclic bisbibenzyls from the liverwortRebouliahemisphaericaand the cell-based screening of their microtubule inhibitory effects.Chin. J. Nat. Med.2009, 7, 123-128.

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