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硕士生导师

李天路

日期:2021-07-28点击:

李天路博士 副教授

山东大学,国家糖工程技术研究中心

联系方式:17615804079;litianlu@sdu.edu.cn

教育经历:

2012.09 – 2016.12,哲学博士,香港大学化学系,导师:李学臣 教授

2008.09 – 2012.06,理学学士,中国药科大学药学专业,导师:徐云根 教授

工作经历:

2020.09 –今 ,副教授,山东大学国家糖工程技术研究中心

2019.01 – 2020.08,助理研究员,山东大学国家糖工程技术研究中心

2017.01 – 2018.12,博士后,密西根州立大学化学系,合作导师:黄雪飞 教授

研究方向:

1.糖肽、糖蛋白、蛋白聚糖的精准制备新方法和新策略的发展

2.基于精准糖肽、糖蛋白、蛋白聚糖结构的糖基功能研究

3.多肽类药物的化学合成、糖基化改造及其药效学研究

荣誉获奖:

2012.09,香港大学,Certificate of Teaching and Learning in Higher Education

2015.09,香港大学,Postgraduate Research Seminar Award

代表性论文:

  1. Tianlu, Li‖; Tong, Li‖; Michael, Linseis‖; Fengshan, Wang;, Rainer F. Winter;, Richard R. Schmidt; Peng, Peng, Catalytic Regioselective Benzoylation of 1,2-trans-Diols in Carbohydrates with Benzoyl Cyanide: The Axial Oxy Group Effect and the Action of Achiral and Chiral Amine Catalysts.ACS Catalysis2020,10, 11406-11416.(‖equal contribution)

  2. Tianlu, Li,* Tong Li, Yajing Sun, Yue Yang, Panpan Lv, Fengshan Wang,Hongxiang Lou, Richard R. Schmidt* and Peng Peng*Regioselective Benzoylation of Unprotected β-Glycopyranosides with Benzoyl Cyanide and an Amine Catalyst – Application to Saponin Synthesis, Organic Chemistry Frontiers2021,8, 260-265.

  3. Tianlu, Li; Weizhun, Yang; Sherif, Ramadan; Xuefei, Huang* Synthesis ofO-Sulfated Human Syndecan-1-like Glyco-polypeptides by Incorporating Peptide Ligation and O-Sulfated Glycopeptide Cassette Strategies.Organic Letters2020,22, 6429-6433.

  4. Aiman Saleh A. Mohammed; Weilu, Tian; Youqin, Zhang; Peng, Peng; Fengshan, Wang*;Tianlu, Li* Leishmania lipophosphoglycan components: A potent target for synthetic neoglycoproteins as a vaccine candidate for leishmaniasis.Carbohydrate Polymers2020,237, 116120.

  5. Tong, Li‖;Tianlu, Li‖; Tongxiao, Cui; Yajing, Sun; Fengshan, Wang; Hongzhi, Cao; Richard, R. Schmidt*; Peng, Peng* Regioselective One-Pot Benzoylation of Triol and Tetraol Arrays in CarbohydratesOrganic Letters2018,20, 3862-3865. (‖equal contribution)

  6. Tianlu, Li; Heng, Liu; Xuechen, Li* Chemical Synthesis of HMGA1a Proteins with Post-translational Modifications via Ser/Thr LigationOrganic Letters2016,18, 5944-5947.

  7. Kang, Jin;Tianlu, Li; Hoi Yee, Chow; Han, Liu; Xuechen, Li* P−B Desulfurization: An Enabling Method for Protein Chemical Synthesis and Site‐Specific DeuterationAngew. Chem. Int. Ed.2017,56, 14607-14611.

  8. Mingyue, Liu; Ming-De, Li*; Jinqing, Huang;Tianlu, Li; Han, Liu; Xuechen, Li; David Lee Phillips* Substituent Effects on the Photodeprotection Reactions of Selected Ketoprofen Derivatives in Phosphate Buffered Aqueous SolutionsSci. Rep.2016,6, 21606.

  9. Jonghan Peter, Lee; Changdong, Liu;Tianlu, Li; Guang, Zhu*; Xuechen,Li* Development of stapled helical peptides to perturb the Cdt1–Mcm6 interactionJ. Pept. Sci.2015,21, 593-598.

  10. Clarence, T. T. Wong;Tianlu, Li; Hiu Yung, Lam; Yinfeng, Zhang; Xuechen, Li* Realizing Serine/Threonine Ligation: Scope and Limitations and Mechanistic Implication ThereofFront. Chem.2014,2.

  11. Yinfeng, Zhang;Tianlu, Li; Xuechen, Li* Synthesis of human growth hormone releasing hormone via three-fragment serine/threonine ligation (STL)Org. Biomol. Chem.2013,11(34), 5584-5587.

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