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硕士生导师

刘长城

日期:2021-07-28点击:

刘长城 博士 助理研究员

山东大学,国家糖工程技术研究中心

山东省青岛市滨海路72号,淦昌苑F座228室,266237

电话:+86-532-5863-1415 (O)

传真:+86-532-5863-1405 (O)

Email: ccliu@sdu.edu.cn

教育经历:

2016 理学博士,北京大学药学院,导师:叶新山 教授

2010 工学学士,山东大学药学院,制药工程系

工作经历:

2017.7-今 助理研究员,山东大学国家糖工程技术研究中心

2016.7-2017.6 研究科学家,北京安必奇生物科技有限公司

研究方向:

生物活性寡糖的高效酶法合成策略的发展;高效生物催化策略的开发;基于生物活性寡糖的疫苗、药物以及免疫疗法的开发。

科研项目:

1. 国家自然科学基金青年科学基金项目,21807064,使用Lewis x系列寡糖改善嵌合抗原受体T细胞在实体瘤组织中的浸润和粘附的研究,2019/01-2021/12,主持

2. 国家重点研发计划,以增加水溶性为导向的合成生物学创制子课题3,2018YFA0902002,2019/07-2024/06,主持

3. 山东省自然科学基金博士基金项目,ZR201709190252,基于肿瘤相关糖抗原的T细胞表位的鉴定与确证,2018/03-2020/12,主持

4. 山东大学未来青年学者,2019.09-2024.08。

发表论文:(*为通讯作者)

1. Kan Zhong, Jinfeng Ye, Xinhao Zhu, Hongzhi Cao, and Chang-Cheng Liu.* Highly efficient biocatalytic cascade for the diversity-oriented synthesis of complex blood group Sda antigens. Green Chem., 2020, 22, 8002-8011.

2. Congcong Chen, Shuaishuai Wang, Madhusudhan Reddy Gadi, He Zhu, Fei Liu, Chang-Cheng Liu,* Lei Li, * Fengshan Wang,* Peixue Ling* and Hongzhi Cao.* Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives. Chem. Commun., 2020, 56, 7549-7552.

3. Jinfeng Ye, Hui Xia, Na Sun, Chang-Cheng Liu, Anran Sheng, Lianli Chi, Xian-Wei Liu, Guofeng Gu, Shu-Qi Wang, Jie Zhao, Ping Wang, Min Xiao, Fengshan Wang, Hongzhi Cao.* Reprogramming the enzymatic assembly line for site-specific fucosylation. Nat. Catal. 2019, 2, 514-522.

4. Tian Gao#, Jingyu Yan#, Chang-Cheng Liu, Angelina S. Palma, Zhimou Guo, Min Xiao, Xi Chen, Xinmiao Liang, Wengang Chai, and Hongzhi Cao.* Chemoenzymatic Synthesis of O-Mannose Glycans Containing Sulfated or Nonsulfated HNK-1 Epitope. J. Am. Chem. Soc. 2019, 141, 19351-19359.

5. Na Lu#, Jinfeng Ye#, Jiansong Cheng#, Aniruddha Sasmal#, Chang-Cheng Liu, Wenlong Yao, Jun Yan, Naazneen Khan, Wen Yi, Ajit Varki, Hongzhi Cao.* Redox-controlled site-specific α2-6-sialylation. J. Am. Chem. Soc. 2019, 141, 4547-4552.

6. Caicai Meng, Aniruddha Sasmal, Yan Zhang, Tian Gao, Chang-Cheng Liu, Naazneen Khan, Ajit Varki, Fengshan Wang,* Hongzhi Cao.* Chemoenzymatic assembly of mammalian O-mannose glycans. Angew. Chem. Int. Ed. 2018, 57, 9003-9007.

7. Chengcheng Song, Xiujing Zheng, Chang-Cheng Liu, Yifa Zhou, Xinshan Ye.* A cancer vaccine based on fluorine-modified sialyl-Tn induces robust immune responses in a murine model, Oncotarget, 2017, 8, 47330-47343.

8. Chang-Cheng Liu, Canjia Zhai, Xiujing Zheng, Xinshan Ye.* Altering the specificity of the antibody response to HIV gp120 with a glycoconjugate antigen, ACS Chemical Biology, 2016, 11, 1702-1709.

9. Chang-Cheng Liu, Xiujing Zheng, Xinshan Ye.* Broadly neutralizing antibody-guided carbohydrate-based HIV vaccine design: challenges and opportunities,ChemMedChem2016, 11, 357-362.

10. Changxin Huo, Xiujing Zheng, An Xiao, Chang-Cheng Liu, Shuang Sun, Zhuo Lv, Xinshan Ye.* Synthetic and Immunological Studies of N-Acyl Modified S-Linked STn Derivatives as Anticancer Vaccine Candidates, Organic Biomolecular Chemistry, 2015, 13, 3677-3690.

11. Chang-Cheng Liu, Xinshan Ye.* Carbohydrate-based cancer vaccines: target cancer with sugar bullets, Glycoconjugate Journal, 2012, 29, 259-271.

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