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硕士生导师

陈宗刚

日期:2021-07-28点击:

陈宗刚博士,副教授,硕士生导师

电话:053258631407

E-mailchenzg@sdu.edu.cn

地址:山东省青岛市即墨滨海路72号山东大学青岛校区淦昌苑F115

教育经历

2004.09 - 2008.01东华大学 化学化工与生物工程学院 博士

2006.06 - 2006.09新加坡国立大学 工程学院生物工程系 合作研究

2001.09 - 2004.03天津工业大学 硕士

工作经历

2010.10 –今 山东大学国家糖工程技术研究中心 任教

2008.09 2010.9清华大学 材料系 博士后

1995.01 2001.07山东泰山制丝有限公司

研究方向

生物材料,组织工程,再生医学,药物载体,医美水凝胶

主要是在分析生物材料微组装、生物功能及形成机理的基础上,发展用于人体组织器官修复与替代的新型医用材料,靶向控释给药系统和医美填充水凝胶。

当前主要工作:

1.蛋白-多糖复合纳米纤维仿生组织修复材料的研究(用于小血管、神经、皮肤、骨、肌腱的修复与再生)

2.组织工程骨植入材料的仿生基础问题研究

3.药物靶向载体控释材料的研究

4.可吸收多糖止血材料和伤口修复材料的应用研究

5.可注射医美填充水凝胶的研究

主持和参与的部分项目

1.山东省重点研发计划,2017GSF18119,肿瘤靶向性透明质酸寡糖修饰的壳聚糖微球药物载体的制备及性能研究,2017.07-2019.12,主持

2.山东省自然科学基金,ZR2016EMM15,透明质酸寡糖修饰的胶原蛋白纳米纤维仿生细胞外基质及其用于组织工程小血管构建的研究,2016.10-2019.06,主持

3.国家自然科学基金面上项目,21472114,新型细菌成孔毒素抑制剂的设计、合成与活性评价,2015.01-2018.12,参加

4.山东大学基本科研业务费资助项目—交叉学科培育项目,2015JC004,基于糖基化胶原仿生细胞外基质的组织工程小血管的构建,2015.01-2017.12,主持

5.山东省科技发展计划,2014GSF118113,基于糖基化修饰的矿化胶原仿生骨修复材料分级自组装,2014.01-2016.12,主持

6.山东省自然科学基金面上项目,ZR2012EMM008,基于蛋白-多糖纳米纤维多层仿生细胞外基质支架的组织工程小血管的体外构建,2012.08-2015.07,主持

7.山东大学自主创新基金,2010TB011,微创原位自固化可注射仿生骨修复材料的研究,2010.10-2012.12,主持

8.国家自然科学基金面上项目,50973052、神经干细胞的支架材料研究,2010.01-2012.12,参加

9.中国博士后基金一等资助项目,20100470011,从纳米到厘米-骨再生植入材料的多级结构仿生研究,2009.10-2010.10,主持

10.国家863计划项目,2008AA03Z305、蛋白-多糖复合纳米纤维用于组织修复的研究,2008.09-2012.12,参加

11.国家自然科学基金面上项目,30570503,胶原蛋白-甲壳胺复合纳米纤维仿生组织细胞间质及与细胞相互作用的研究,2006.1-2008.12,参加

代表论文

1. Weibin Jia, Min Li, Liling Liu, Hang Zhou, Xiankun Liu, Guofeng Gu, Min Xiao, Zonggang Chen*. Fabrication and assessment of chondroitin sulfate-modified collagen nanofibers for small-diameter vascular tissue engineering applications. Carbohyd Polym, 2021, 257: UNSP-117573.

2. Min Li, Weibin Jia, Xiuli Zhang, Hongjuan Weng, Guofeng Gu, Zonggang Chen*. Hyaluronic acid oligosaccharides modified mineralized collagen and chitosan with enhanced osteoinductive properties for bone tissue engineering. Carbohyd Polym, 2021, 260: UNSP-117780.

3. Weibin Jia, Min Li, Hongjuan Weng, Guofeng Gu, Zonggang Chen *. Carbohyd Polym. Design and comprehensive assessment of a biomimetic tri-layer tubular scaffold via biodegradable polymers for vascular tissue engineering, Mat Sci Eng C-Mater, 2020, 110: UNSP-110717.

4. Min Li, Xiuli Zhang, Weibi Jia, Qin Wang, Yang Liu, Xianpeng Wang, Chuandong Wang, Jianjun Jiang, Guofeng Gu, Zhongwu Guo, Zonggang Chen*. Improving in vitro biocompatibility on biomimetic mineralized collagen bone materials modified with hyaluronic acid oligosaccharide, Mat Sci Eng C-Mater, 2019, 104: UNSP-110008.

5. Lingzhi Kang, Weibin Jia, Min Li, Qin Wang, Chuandong Wang, Yang Liu, Xianpeng Wang, Lan Jin, Jianjun Jiang, Guofeng Gu, Zonggang Chen*. Hyaluronic acid oligosaccharide-modified collagen nanofibers as vascular tissue-engineered scaffold for promoting endothelial cell proliferation, Carbohydrate Polymers, 2019, 223: UNSP-115106.

6. Weibin Jia, Min Li, Lingzhi Kang, Guofeng Gu, Zhongwu Guo, Zonggang Chen*. Fabrication and Comprehensive Characterization of Biomimetic Extracellular Matrix Electrospun Scaffold for Vascular Tissue Engineering Applications. J Mater Sci, 2019, 54(15): 10871-10883.

7. Fengjuan Zou#, Runrun Li#, Jianjun Jiang, Xiumei Mo, Guofeng Gu, Zhongwu Guo, Zonggang Chen*. Mechanical enhancement and in vitro biocompatibility of nanofibrous collagen-chitosan scaffolds for tissue engineering. J Biomat Sci-Polym E, 2017, 28(18): 2255-227.

8. Siqiang Li, Hong Wang, Juncai Ma, Guofeng Gu*,Zonggang Chen*, and Zhongwu Guo*. One-pot four-enzyme synthesis of thymidinediphosphate-L-rhamnose. Chem Commun, 2016, 52(97): 13995-13998.

9. Xin Zhao,Zonggang Chen*, Guofeng Gu, Zhognwu Guo *. Recent advances in the research of bacterial glucuronosyltransferases. J Carbohyd  Chem, 2016, 35(4): 201-223.

10. Zonggang Chen#*, Xiuli Zhang#, Lingzhi Kang#, Fei Xu, Zhaoling Wang, Fuzhai Cui, Zhongwu Guo. Recent progress in injectable bone repair materials research. Front Mater Sci, 2015, 9(4): 332-345.

11. Zonggang Chen*, Lingzhi Kang, Qing-Yuan Meng, Huanye Liu, Zhaoling Wang, Zhongwu Guo*, Fuzhai Cui*. Degradability of injectable calcium sulfate/mineralized collagen-based bone repair material and its effect on bone tissue regeneration. Mater Sci Eng C-Mater, 2014, 45(1): 94-102.

12. Zonggang Chen*, Lingzhi Kang, Zhaoling Wang, Fei Xu, Guofeng Gu, Fuzhai Cui, Zhongwu Guo*. Recent progress in the research of biomaterials regulating cell behavior. RSC Adv, 2014, 4(109): 63807~63816.

13. Zonggang Chen*, Huanye Liu, Xi Liu, Xiaojie Lian, Fuzhai Cui*. Improved Workability of Injectable Calcium Sulfate Bone Cement by Regulation of Self-setting Properties. Mat Sci Eng C-Mater, 2013, 33(3): 1048~1053.

14. Ning-Min Hu#, Zonggang Chen# (Co-first author), Xi Liu, Huanye Liu, Xiaojie Lian, Xiumei Wang, Fu-Zhai Cui. Mechanical properties and in vitro bioactivity of injectable and self-setting calcium sulfate/nano-HA/collagen bone graft substitute. J Mech Behav Biomed, 2012, 12: 119-128.

15. Zonggang Chen*, Huanye Liu, Xi Liu and Fu-Zhai Cui. Injectable calcium sulfate/mineralized collagen-based bone repair materials with regulable self-setting properties. J Biomed Mater Res A, 2011, 99A(4): 554-563.

16. Zonggang Chen, Peiwei Wang, Bo Wei, Xiumei Mo, Fu-zhai Cui. Electrospun collagen-chitosan nanofiber: a biomimetic extracellular matrix for endothelial cell and smooth muscle cell. ACTA Biomater, 2010, 6 (2): 372-382.

17. Xi Liu, Xiumei Wang, Zonggang Chen, Fu-zhai Cui. Huan-Ye Liu, Keya Mao, Yan Wang Injectable bone cement based on mineralized collagen.J Biomed Mater Res B. 2010, 94B(1):72-79.

18. Zonggang Chen, Bo Wei, Xiumei Mo, C.T. Lim, Seeram Ramakrishna, Fu-zhai Cui. Mechanical Properties of Electrospun Collagen-Chitosan Complex Single Fibers and Membrane.Mat Sci Eng C-Mater, 2009, 29 (8): 2428-2435.

19. Zonggang Chen, Bo Wei, Xiumei Mo, Fu-zhai Cui. Diameter control of electrospun chitosan-collagen fibers. J Polym Sci Phys, 2009, 47 (19): 1949-1955.

20. Zonggang Chen, Xiumei Mo. Intermolecular interactions in electrospun collagen -chitosan complex nanofibers. Carbohyd Polym, 2008, 72 (3): 410418.

21. Zonggang Chen, Xiumei Mo, Fengling Qing. Electrospinning of Collagen-Chitosan Complex.Mater Lett, 2007, 61 (16): 34903494.

授权专利

(1) 陈宗刚, 贾维彬, 康灵芝, 郭忠武. 一种透明质酸寡糖修饰的胶原蛋白纳米纤维血管修复材料及其制备方法.中国专利 ZL201711075437.1. 授权日期:2021.2.19

(2) 陈宗刚, 张秀丽, 栗敏, 顾国锋, 郭忠武. 一种透明质酸寡糖修饰的矿化胶原仿生骨修复材料及其制备方法. 中国专利ZL201710192690.9.  授权日期:2019.12.31.

(3) 陈宗刚, 张秀丽, 栗敏, 顾国锋, 郭忠武. 一种透明质酸寡糖修饰的矿化胶原仿生骨修复材料.中国专利 ZL201910940492.5. 授权日期:2020.6.30.

(4) 陈宗刚; 邹凤娟; 顾国峰; 郭忠武; 一种包载多西紫杉醇的透明质酸寡糖-壳聚糖微球及其制备方法与应用. 中国专利 ZL201810348940.8. 授权日期:2018.4.18.

(5) 陈宗刚,莫秀梅.中国发明专利:胶原蛋白和壳聚糖复合纳米纤维静电纺丝的制备方法. 中国专利 ZL 200610116988.3. 授权日期:2009.9.2.

获奖和名誉

1. 2015-2020 连续入选中国高被引学者榜单

2. 200812月,水溶性医用几丁糖的制备技术及应用,获“上海市科学技术奖”一等奖。


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