孙斌 医学博士

副教授 博士生导师

济南市文化西路44号，山东大学药学院新科研楼302室

联系电话：0531-88382235

联系邮箱：sunbin@sdu.edu.cn

学习和工作经历

2001.09-2005.07，山东大学，药学院药学专业，理学学士；

2005.09-2010.07，山东大学，药学院药物化学专业，医学博士（导师：娄红祥教授）；

2008.09-2009.09，普渡大学，药学院药物化学专业，联合培养博士研究生。

2010.07-至今，山东大学国家糖工程技术研究中心，讲师，副教授；

2018年获山东大学“青年学者未来计划”人才计划支持。

研究方向

1.抗肿瘤和抗真菌活性天然产物的合成、衍生物制备和作用机制研究；

2.一氧化氮供体型化合物的设计、合成和抗肿瘤活性研究；

3.抗凝血创新药物的研究与开发。

主持项目

1.国家自然科学基金，苯醌还原酶2抑制剂的设计、合成及其化学预防作用机制研究（811021319）

2.国家科技重大专项子课题，凝血酶受体-1抑制剂1.1类抗血小板新药Andropaxar的临床前研究（2019ZX09301112）

3.山东省自然科学基金，基于溶酶体的双联苄类一氧化氮供体衍生物制备及逆转肿瘤多药耐药研究（ZR2024MH171）

4.山东省自然科学基金，基于苯醌还原酶2晶体结构的白藜芦醇类似物的设计、合成和活性研究（ZR2011HQ024）

5.山东省重点研发计划重大新药创制子课题，小分子PAR-1抑制剂1.1类抗凝血新药舒心帕沙的临床前研究（2017CXGC1403）

6.中国博士后第49批面上项目，苯醌还原酶2抑制剂的设计、合成及其化学预防作用机制研究（20110491602）

7.山东省重点研发计划公益类项目，靶向溶酶体的双联苄衍生物的合成、抗肿瘤活性研究和成药性研究（GG201709190112）

8.山东大学青年学者未来计划项目，肿瘤靶向性一氧化氮供体型化合物的制备及抗肿瘤作用机制研究（2018WLJH41）

代表论文

1. Jia-yu Sun, Si-jie Qi, Qian Chen, Ke-xin Liu, Hao-yu Liu, Hong-bo Zheng, Bin Sun*, Hongxiang Lou*, Design, Synthesis, and Biological Evaluation of Marchantin C-NO Donor Hybrids for Overcoming Pgp-Mediated Drug Resistance by Targeting Lysosome, Journal of Medicinal Chemistry, 2025, 68(5): 5503-5528

2. Si-jie Qi, Ke-xin Liu, Hao-yu Liu, Gao-qiang Zhang, Hong-bo Zheng, Jia-yu Sun, Bin Sun*, Hong-xiang Lou*, Discovery of potent quinone oxidoreductase 2 inhibitors to overcome TRAIL resistance of non-small cell lung cancer, European Journal of Medicinal Chemistry, 2025, 288:117382

3. Xiaoyu Zhao^#, Bin Sun^#, Hongbo Zheng, Jun Liu, Xiaoning Wang*, Hongxiang Lou*, Synthesis and biological evaluation of 6-hydroxyl C-aryl glucoside derivatives as novel sodium glucose co-transporter 2 (SGLT2) inhibitors, Bioorganic & Medicinal Chemistry Letters, 2018, 28: 2201-2205.

4. Changyi Cui, Jun Liu, Hongbo Zheng, Xueyang Jin, Xiaoyu Zhao, Wenqiang Chang, Bin Sun*, Hongxiang Lou*, Diversity-oriented synthesis of pyrazoles derivatives from flavones and isoflavones leads to the discovery of promising reversal agents of fluconazole resistance in Candida albicans, Bioorganic & Medicinal Chemistry Letters, 2018, 28: 1545-1549.

5. Jun Liu^#, Bin Sun^#, Xiaoyu Zhao, Jie Xing, Yanhui Gao, Wenqiang Chang, Jianbo Ji, Hongbo Zheng, Changyi Cui, Aiguo Ji*, Hongxiang Lou*, Discovery of potent orally active protase-activated receptor 1 (PAR1) antagonist based on andrographolide, Journal of Medicinal Chemistry,2017, 60 (16): 7166-7185

6. Bin Sun^#, Jun Liu^#, Yun Gao, Hongbo Zheng, Lin Li, Qingwen Hu, Huiqing Yuan, Hongxiang Lou*, Design, synthesis, and biological evaluation of nitrogen-containing macrocyclic bisbibenzyl derivatives as potent anticancer agents by targeting the lysosome, European Journal of Medicinal Chemistry, 2017, 136:603-618

7. Bin Sun, Lin Li, Qingwen Hu, Hongbo Zheng, Hui Tang, Huanmin Niu, Huiqing Yuan, Hongxiang Lou*, Design, synthesis, biological evaluation and molecular modeling study of novel macrocyclic bisbibenzyl analogues as antitubulin agents, European Journal of Medicinal Chemistry, 2017, 129:186-208

8. Bin Sun, Ming Zhang, Ying Li, Qingwen Hu, Hongbo Zheng, Wenqiang Chang, Hongxiang Lou*, Synthesis of riccardin D derivatives as potent antimicrobial agents, Bioorganic & Medicinal Chemistry Letters, 2016, 26 (15): 3617-3620

9. Bin Sun, Lin Li, Qingwen Hu, Fei Xie, Hongbo Zheng, Huanmin Niu, Huiqing Yuan, Hongxiang Lou*, Design, synthesis and biological evaluation of novel macrocyclic bisbibenzyl analogues as tubulin polymerization inhibitors, European Journal of Medicinal Chemistry, 2016, 121: 484-499

10. Xigong Liu^#, Bin Sun^#, Zhiyu Xie, Xiaojun Qin, Lei Liu, Hongxiang Lou*, Manganese dioxide-methanesulfonic acid promoted direct dehydrogenative alkylation of sp3 C-H bonds adjacent to a heteroatom, Journal of Organic Chemistry, 2013, 78 (7): 3104-3112

11. Juan Jiang^#, Bin Sun^#, Yanyan Wang, Min Cui, Li Zhang, Changzhi Cui, Yanfeng Wang, Xigong Liu, Hongxiang Lou*, Synthesis of macrocyclic bisbibenzyl derivatives and their anticancer effects as anti-tubulin agents, Bioorganic & Medicinal Chemistry, 2012, 20 (7): 2382-2391

12. Guangmin Xi^#, Bin Sun^#, HuiHui Jiang, Feng Kong, Huiqing Yuan, Hongxiang Lou*, Bisbibenzyl derivatives sensitize vincristine- resistant KB/VCR cells to chemotherapeutic agents by retarding P-gp activity, Bioorganic & Medicinal Chemistry, 2010, 18 (18): 6725-6733

13. Bin Sun, Juma Hoshino, Katie Jermihov, Laura Marler, John M. Pezzuto, Andrew D. Mesecar, Mark Cushman, Synthesis, and Biological Evaluation of Resveratrol Analogues as Aromatase and Quinone Reductase 2 Inhibitors for Chemoprevention of Cancer, Bioorganic & Medicinal Chemistry, 2010, 18 (14): 5352-5366

14. Bin Sun, Huiqing Yuan, Guangmin Xi, Yudao Ma*, Hongxiang Lou*, Synthesis and multidrug resistance reversal activity of dihydroptychantol A and its novel derivatives, Bioorganic & Medicinal Chemistry, 2009, 17 (14): 4981-4989.