1

Developing Acid-Responsive   Glyco-Nanoplatform Based Vaccines for Enhanced Cytotoxic T-lymphocyte   Responses Against Cancer and SARS-CoV-2

Yanan Gao, Qingyu Zhao, Huiling Dong, Min   Xiao, Xuefei Huang, and Xuanjun Wu*

Advanced Functional Materials. 2021, 31,   2105059

18.808

2

Chemoenzymatic Synthesis of 9NHAc-GD2   Antigen to Overcome Hydrolytic Instability of O-Acetylated-GD2 for Anticancer   Conjugate Vaccine Development

Xuanjun Wu, Jinfeng Ye, Andrew T.   DeLaitsch, Zahra Rashidijahanabad, Shuyao Lang, Tayeb Kakeshpour, Yuetao   Zhao, Sherif Ramadan, Paulo Vilar Saavedra, Vilma Yuzbasiyan-Gurkan, Hongzhi   Cao*, Jeffrey C. Gildersleeve* , Xuefei Huang*

Angewandte Chemie International   Edition. 2021, 60, 24179–24188

15.336

3

Discovery of exolytic heparinases and their   catalytic mechanism and potential application

Qingdong Zhang, Hai-Yan Cao, Lin Wei,   Danrong Lu, Min Du, Min Yuan, Deling Shi, Xiangxue Chen, Peng Wang, Xiu-Lan   Chen, Lianli Chi, Yu-Zhong Zhang*, Fuchuan Li *

Nature Communications. 2021, 12, 1263

13.611

4

Chemoenzymatic modular assembly   of O-GalNAc glycans for functional glycomics

Shuaishuai Wang,Congcong Chen,   Madhusudhan Reddy Gadi,Varma Saikam, Ding Liu,He Zhu,, Roni Bollag, Kebin   Liu, Xi Chen, Fengshan Wang, Peng George Wang* ,Peixue Ling*, Wanyi Guan*,   Lei Li *

Nature Communications.2021, 12, 3573

13.611

5

Facile Enzymatic Synthesis of Diverse   Naturally-Occurring
  β‑D‑Mannopyranosides Catalyzed by Glycoside Phosphorylases

Jing Liu, Xuefei Yin, Zitao Li, Xiaocong   Wu, Zhaoxuan Zheng, Junqiang Fang, Guofeng Gu, Peng G. Wang, Xianwei Liu*

ACS Catalysis. 2021, 11, 2763−2768

13.084

6

O-Glycosyl Trichloroacetimidates as   Glycosyl Donors and Platinum(IV) Chloride as a Dual Catalyst Permitting   Stereo- and Regioselective Glycosidations

Tong Li, Tianlu Li, Haoru Zhuang, Fengshan   Wang, Richard R. Schmidt*, Peng Peng*

ACS Catalysis. 2021, 11, 16, 10279–10287

13.084

7

Improve Stability of Bioactive   Peptides by Enzymatic Modular Synthesis of Peptides with O‑Linked Sialyl   Lewis x

Xiaoju Zheng, Lin Zhu, Tianlu   Li, Wenjia Xu, Dongke Liu, Juzheng Sheng, Hongzhi Cao, Yikang Shi,Fengshan   Wang*

ACS Catalysis. 2021, 11, 8042−8048

13.084

8

A versatile photothermal vaccine based on   acid-responsive glyco-nanoplatform for synergistic therapy of cancer

Yanan Gao, Qingyu Zhao, Min Xiao,Xuefei   Huang, Xuanjun Wu*

Biomaterials.2021, 273, 120792

12.479

9

Total Synthesis of the   Tetrasaccharide Haptens of Vibrio vulnificus MO6-24 and BO62316 and   Immunological Evaluation of Their Protein Conjugates

Han Zhang, Xiaohan Wang, Youhui   Meng, Xiaoyu Yang, Qingpeng Zhao, Jian Gao*

JACS Au. 2021

10

Gram-scale production of sugar nucleotides   and their derivatives†

Shuang Li,Shuaishuai Wang, Yaqian Wang,   Jingyao Qu,Xian-wei Liu,Peng George Wang, Junqiang Fang*

Green Chemistry.2021, 23,2628-2633

10.182

11

A novel chemical biology and computational   approach to expedite the discovery of new-generation polymyxins against   life-threateningAcinetobacter baumannii

Xukai Jiang, Nitin A. Patil, Mohammad A. K.   Azad,Hasini Wickremasinghe,Heidi Yu, Jinxin Zhao,Xinru Zhang,Mengyao Li,Bin   Gong, Lin Wan, Wendong Ma,Philip E. Thompson, Kai Yang, d Bing Yuan, Falk Schreiber,Lushan Wang,Tony Velkov,Kade   D. Roberts, Jian Li*

Chemical Science. 2021, 12, 12211-12220

9.821

12

Development of bifunctional biosensors for   sensing and dynamic control of glycolysis flux in metabolic engineering.

Yuan Zhu, Ying Li, Ya Xu, Jian Zhang,   Linlin Ma, Qingsheng Qi*, Qian Wang*

Metabolic Engineering. 2021,142–151.

9.783

13

A novel chondroitin sulfate E from   Dosidicus gigas cartilage and its antitumor metastatic activity

Chune Peng, Qingbin Wang, Runmiao Jiao,   Yingying Xu, Naihan Han, Wenshuang Wang , Changxiang Zhu*, Fuchuan Li *

Carbohydrate Polymers. 2021, 262,   117971-117979

9.381

14

Hyaluronic acid oligosaccharides modified   mineralized collagen and chitosan with enhanced osteoinductive properties for   bone tissue engineering

Min Li.Weibin Jia, Xiuli Zhang, Hongjuan Weng, Guofeng Gu,   Zonggang Chen*

Carbohydrate polymers. 2021, 260,117780

9.381

15

Fabrication and assessment of chondroitin   sulfate-modified collagen nanofibers for small-diameter vascular tissue   engineering applications

Weibin Jia, Min Li. Liling Liu, Hang Zhou,   Guofeng Gu, Min Xiao, Zonggang Chen*

Carbohydrate polymers,.2021, 257,117753

9.381

16

Enzyme-Induced Transformable   Peptide Nanocarriers with Enhanced Drug Permeability and Retention to Improve   Tumor Nanotherapy Efficacy

Zhongying Gong, Baolong Zhou,   Xiaoying Liu, Juanjuan Cao, Zexin Hong, Jingye Wang, Xirui Sun, Xiaomeng   Yuan, Haining Tan*, Hongjie Ji, Jingkun Bai*

ACS Appl Mater   Interfaces.2021,13, 47, 55913–55927

9.229

17

Modular tuning engineering and versatile   applications of genetically encoded biosensors.

Jian Zhang, Qingxiao Pang, Qi Wang,   Qingsheng Qi*, Qian Wang*.

Critical Reviews in Biotechnology. 2021, 6,   1-18.

8.429

18

Study of chondroitin sulfate E   oligosaccharide as a promising complement C5 inhibitor for osteoarthritis   alleviation

Chen Yu, Hengchang Zang, Cui Yang, Dong   Liang, Shuang Quan, Danyang Li, Yanni Li, Qin Dong, Fengshan Wang, Lian Li*

Materials Science and Engineering: C.   2021,112234

7.328

19

Coarse-grained simulations uncover   Gram-negative bacterial defense against polymyxins by the outer membrane

Xukai Jiang, Yuliang Sun, Kai Yang, Bing   Yuan, Tony Velkov, Lushan Wang, Jian Li*

Computational and Structural Biotechnology   Journal. 2021, 19, 3885-3891

7.274

20

The Second Chrosome Promotes   the Adaption of the Genus Flammeovirga to Complex Environments

Zewei Feng#, Zheng Zhang#, Yu   Liu, Yuanyuan Cheng, Wei Hu, Yuezhong Li, Wenjun Han*

Microbiology Spectrum.   2021,9(3), e00980-21.

7.17

21

Cancer cell preferential penetration and   pH-responsive drug delivery of oligorutin

Weiying Hong, Chang-Cheng Liu, Henan Zhang,   Zhiyong Chen, Min Xiao*,Li Xu*

Biomacromolecules. 2021, 22, 3679−3691

6.988

22

Coupling Liquid Chromatography and Tandem   Mass Spectrometry to Electrophoresis for In-Depth Analysis of   Glycosaminoglycan Drugs: Heparin and the Multicomponent Sulodexide

Anran Sheng, Qingqing Chen, Mengqi Yu,   Ruiqi Xiao, Tianji Zhang, Zhiyu Wang, Robert J. Linhardt, Xiaojun Sun,* Lan   Jin,* Lianli Chi*

Analytical Chemistry. 2021, 93, 1433−1442

6.986

23

Chondroitin Sulfate/Dermatan   Sulfate-Protein Interactions and Their Biological Functions in Human   Diseases: Implications and Analytical Tools

Bin Zhang, Lianli Chi*

Frontiers in Cell and Developmental   Biology. 2021,9, 693563

6.684

24

Research on the Structure of Peanut Allergen   Protein Arah1 Based on Aquaphotomics

Mengqi Zhang, Liang Liu, Cui Yang, Zhongyu   Sun,Xiuhua Xu, Lian Li*, Hengchang Zang*

Frontiers in Nutrition. 2021(1), 8696355

6.576

25

Synthesis and immunological evaluation of   synthetic peptide based anti-SARS-CoV-2 vaccine candidates

Qingyu Zhao, Yanan Gao, Min Xiao,Xuefei   Huang , Xuanjun Wu*

Chemical Communications.2021, 57,   1474–1477.

6.222

26

Capture-Release Strategy   Facilitates Rapid Enzymatic Assembly
  of Oligosaccharides

Wenyuan Fang,Kan Zhong,Jiansong   Cheng,Xian-Wei Liu,Chang-Cheng Liu*,Zhongfu Wang,Hongzhi Cao*

Chinese Journal of Chemistry.   2021, 39

6

27

Antimicrobial Peptides: An   Update on Classifications and Databases

Ahmer Bin Hafeez, Xukai Jiang,   Phillip J. Bergen, Yan Zhu*

International Journal of   Molecular Sciences . 2021, 22, 11691

5.924

28

Vibrational Spectroscopy in Assessment of   Early Osteoarthritis—A Narrative Review

Yu Chen, Zhao Bing, Li Yan, Zang Hengchang,   Li Lian*

International   Journal of Molecular Sciences. 2021, 22(10),5235

5.924

29

Direct Isomaltulose Synthesis From Beet   Molasses by Immobilized Sucrose Isomerase

Qin-Qing Wang, Ming Yang, Jian-Hua Hao*,   Zai-Chao Ma*

Frontiers in Bioengineering and   Biotechnology. 2021, 9, 691547

5.89

30

A Technical System for the   Large-Scale Application of Metabolites From Paecilomyces variotii SJ1 in   Agriculture

Qingbin Wang, Chune Peng, Liran   Shi, Zhiguang Liu, Dafa Zhou, Hui Meng,Hongling Zhao, Fuchuan Li* , Min   Zhang*

Front Bioeng Biotechnol. 2021,   12, 9, 671879.

5.89

31

Biochemical Characterization   and Synthetic Application of
  α-1,3-Glucosyltransferase from Pneumococcus Serotype
  18C

Hong Wang,Chongzhen Sun,Xuan   Sun, Le Zhang, Jielin Zhao,Min Liang,Min Xiao,Guofeng Gu*

ChemCatChem. 2021, 13,   3350–3356

5.686

32

Cisplatin enhances protein O‑GlcNAcylation   by altering the activity of OGT, OGA and AMPK in human non‑small cell lung   cancer cells

Di Wang, Jiaan Wu, Dandan Wang, Xiaoyan   Huang, Naining Zhang, Yikang Shi*

International Journal of Oncology. 2021,   58(6), 27.

5.65

33

A Novel β-Glucosidase From   Chryseobacterium scophthalmum 1433 for Efficient Rubusoside Production From   Stevioside

Zhenxin Yan, Xueting Cao, Xiao   Yang, Shida Yang, Li Xu, Xukai Jiang*, Min Xiao*

Frontiers Microbiology.2021, 12, 744914

5.64

34

Novel dTDP-L-rhamnose synthetic   enzymes (RmlABCD) from Saccharothrix syringae CGMCC 4.1716 for One-pot   Four-enzyme Synthesis of dTDP-L-rhamnose

Shida Yang, Xiaonan An, Guofeng   Gu, Zhenxin Yan, Xukai Jiang, Li Xu*, Min Xiao*

Frontiers Microbiology. 2021,   12, 772839

5.64

35

Comparative molecular dynamics simulations   identify a salt-sensitive loop responsible for the halotolerant activity of   GH5 cellulases

Yuxuan Song, Xiuyun Wu, Yue Zhao, Xukai   Jiang*, Lushan Wang

Journal of Biomolecular Structure and   Dynamics. 2021, 27, 1-11

无

36

Identification of four secreted   aspartic proteases-like proteins associated with sophorolipids synthesis in   Starmerella bombicola CGMCC 1576

Jun liu, Xinyu Zhang, Guoqin   Zhao, Xin Song

Frontiers in Microbiology.   2021,12,737244

5.64

37

NMR Characterization of the   Interactions Between Glycosaminoglycans and Proteins

Changkai Bu, Lan Jin*

Frontiers in Molecular   Biosciences. 2021, 8, 646808

5.639

38

Fine tuning the glycolytic fux ratio   of EP-bifdo pathway for mevalonate production by enhancing   glucose-6-phosphate dehydrogenase (Zwf) and CRISPRi suppressing   6-phosphofructose kinase (PfkA) in Escherichia coli

Ying Li1, He Xian, Ya Xu, Yuan Zhu, Zhijie   Sun*, Qian Wang*, Qingsheng Qi

Microbial Cell Factories.2021, 20:32

5.328

39

Cell-based high-throughput screening of   polysaccharide biosynthesis hosts

Zi-xu Liu, Si-ling Huang, Jin   Hou,Xue-ping Guo, Feng-shan Wang, Ju-zheng Sheng.

Microbial Cell Factories. 2021,   20 (1), 62.

5.328

40

Regioselective benzoylation of unprotected   β-glycopyranosides with benzoyl cyanide and an amine catalyst – application   to saponin synthesis

Tianlu Li, Tong Li, Yajing Sun, Yue Yang,   Panan Lv, Fengshan Wang, Hongxiang Lou, Richard R. Schmidt*, Peng Peng*

Organic Chemistry Frontiers. 2021, 8 (2),   260-265.

5.281

41

Two-step enzymatic conversion of   rebaudioside A into a mono-α-1, 4-glucosylated rebaudioside A derivative

Wenzheng Wang, Yajing Sun, Peng Peng,   Guofeng Gu, Guoying Du, Li Xu*, Min Xiao*

Journal of Agricultural and Food   Chemistry.2021, 69, 8, 2522–2530

5.279

42

Low molecular weight   chondroitin sulfate ameliorates pathological changes
  in 5XFAD mice by improving various functions in the brain

Na Zhao a, Lidan Wu a, Xinke   Zhang b, Wenjie Jiang *, Fengshan Wang*

Neuropharmacology.2021,199,108796

5.251

43

Glycosaminoglycan-Protein Interactions and   Their Roles in Human Disease

Deling Shi, Anran Sheng, Lianli Chi*

Frontiers in Molecular   Biosciences. 2021,8, 639666

5.246

44

Comparison of Biochemical   Characteristics, Action Models,and Enzymatic Mechanisms of a Novel Exolytic   and Two Endolytic Lyases with Mannuronate Preference

Lianghuan Zeng, Junge Li ,   Yuanyuan Cheng, Dandan Wang , Jingyan Gu, Fuchuan Li ,Wenjun Han*

Marine Drugs. 2021, 19, 706

5.118

45

Potassium permanganate assisted organosolv   pretreatment enhances enzymatic hydrolysis of corn stover

Haiyan Chen, Xuezhi Li, Shaoyang Yu, Yuqi   Qin*, Yinbo Qu, Jian Zhao*.

GCB Bioenergy. 2021,13,665–678.

4.745

46

Immunogenicity Assessment of   Different Segments and Domains of Group a Streptococcal C5a Peptidase and   Their Application Potential as Carrier Protein for Glycoconjugate  Vaccine Development

Guirong Wang, Jielin Zhao,   Yisheng Zhao, Subo Wang, Shaojie Feng, Guofeng Gu *

Vaccines. 2021, 9, 139

4.422

47

Reinvestigation of N,N‑Diacetylimido-Protected   2‑Aminothioglycosides in O‑Glycosylation: Intermolecular Hydrogen Bonds   Contributing to 1,2-Orthoamide Formation

Liming Shao, Zhenni Huo, Na   Lei, Min Yang, Zehuan He, Yongliang Zhang, Qinlong Wei, Changsheng Chen, Mei   Xiao, Fei Wang, Guofeng Gu, Feng Cai*

Journal of Organic Chemistry.   2021, 86, 19, 13212–13230

4.354

48

Study on the relationships   between molecular weights of chondroitin sulfate oligosaccharides and   Aβ-induced oxidative stress and the related mechanisms

Na Zhao, Jie Meng, Wenjie   Jiang, Wenjia Xu, Chunhui Liu,Fengshan Wang*

Glycobiology. 2021, 31,4,   492–507

4.313

49

A CPD photolyase gene PnPHR1 from Antarctic   moss Pohlia nutans is involved in the resistance to UV-B radiation and   salinity stress

Huijuan Wang, Hongwei Liu, Qian Yu, Fenghua   Fan, Shenghao Liu, Guihua Feng, Pengying Zhang*

Plant Physiology and Biochemistry. 2021,   167: 235–244

4.27

50

Crystal structures of   γ-glutamylmethylamide synthetase provide insight into bacterial metabolism of   oceanic monomethylamine

Ning Wang, Xiu-Lan   Chen, Chao Gao, Ming Peng, Peng Wang, Na   Zhang, Fuchuan Li, Gui-Peng Yang, Qing-Tao   Shen, Shengying Li, Yin Chen, Yu-Zhong Zhang*, Chun-Yang   Li*

Journal of Biological Chemistry.2021,   296, 100081

4.238

51

Integrated Utilization of Dairy   Whey in Probiotic -Galactosidase Production and Enzymatic Synthesis of   Galacto-Oligosaccharides

Feiyu Duan, Renfei Zhao, Jingyi   Yang, Min Xiao*, Lili Lu*

Catalysts. 2021, 11, 658

4.146

52

Water as a probe to understand the   traditional Chinese medicine extraction process with near infrared   spectroscopy: A case of Danshen (Salvia miltiorrhiza Bge) extraction process

Lele Gao, Lliang Zhong, Jin Zhang, Mengqi   Zhang, Yingzi Zeng, Lian Li*, Hengchang Zang*

Spectrochimica Acta Part A: Molecular and   Biomolecular Spectroscopy. 2021,(244),118854

4.098

53

Synthesis and Immunological Evaluation of   the Unnatural β-linked Mucin-1 Thomsen-Friedenreich Conjugate

Xuanjun Wu, Hunter McFall-Boegeman, Zahra   Rashidijahanabad, Kunli Liu, Christian Pett, Jin Yu, Manuel Schorlemer, Sherif Ramadan, Sandra   Behren, Ulrika Westerlindde, Xuefei   Huang*

Organic & Biomolecular Chemistry. 2021,   19, 2448–2455

3.876

54

Enzymatic modular assembly of hybrid Lewis   antigens

Hui Xia,Jinfeng Ye, Hongzhi Cao,Xianwei   Liu,Yan Zhang *,Chang-Cheng Liu*

Organic & Biomolecular Chemistry. 2021,   19, 8041

3.876

55

An anti-biofilm material: polysaccharides   prevent the precipitation reaction of silverions and chloride ions and lead   to the synthesis of nano silver chlorid

Kun Li, Zhaoxi Liu, Xiaoyu Liu, Lei Wang,   Jiayu Zhao,Xunlian Zhang,Yun Kong∗, Min Chen∗

Nanotechnology.2021,32,315601

3.874

56

Investigation of action pattern of a novel   chondroitin sulfate/dermatan sulfate 4-O-endosulfatase

Wenshuang Wang , Cédric   Przybylski, Xiaojuan Cai, Chrystel Lopin-Bon, Runmiao   Jiao, Liran Shi, Kazuyuki Sugahara, José L Neira, Régis   Daniel∗, Fuchuan Li∗

Biochemical Journal. 2021,478(2),281-298.

3.857

57

Disruption of the Trichoderma   reesei gul1 gene stimulates hyphal branching and reduces broth viscosity in   cellulase production

Qinqin Zhao, Qin Liu, Qi Wang,   Yuqi Qin, Yaohua Zhong, Liwei Gao, Guodong Liu*, Yinbo Qu

Journal of Industrial   Microbiology and Biotechnology 2021, 48, kuab012

3.346

58

A new perspective in understanding the   dissolution behavior of nifedipine controlled release tablets by NIR   spectroscopy with aquaphotomics

Lanling Liu, Kefan Zhang,Zhongyu Sun, Qin   Dong ,Lian Li*, Hengchang Zang*

Journal of Molecular Structure. 2021(1230),129872

3.196

59

Penicillium oxalicum S-adenosylmethionine   synthetase is essential for the viability of fungal cells and the expression   of genes encoding cellulolytic enzymes

Yueyan Hu, Kaili Zhao, Yinbo Qu, Xin Song,   Jian Zhao, Yuqi Qin*

Fungal Biology. 2021, 125(1),1-11

3.099

60

CRISPR/Cas9-mediated genome   editing in Penicillium oxalicum and Trichoderma reesei

Qi Wang, Qinqin Zhao, Qin Liu,   Xin He, Yaohua Zhong, Yuqi Qin, Liwei Gao, Guodong Liu*, Yinbo Qu

Biotechnology Letters. 2021,   43, 495–502

2.461

61

The flavonoid 3′-hydroxylase gene from the Antarctic moss Pohlia   nutans is involved in regulating oxidative and salt stress tolerance.

Hongwei Liu, Shenghao Liu, Huijuan Wang,   Kaoshan Chen, Pengying Zhang*

Biotechnology and Applied Biochemistry.   2021, 1–11.

2.431

62

Efficient Constitutive   Expression of Cellulolytic Enzymes in Penicillium oxalicum for Improved   Efficiency of Lignocellulose Degradation

Pankajkumar Ramdas Waghmare,   Pratima Pankajkumar Waghmare, Liwei Gao, Wan Sun, Yuqi Qin, Guodong   Liu*, Yinbo Qu

Journal of Microbiology and   Biotechnology 2021,31(5),740–746

2.351

63

Robust one-pot multi-enzyme   polysaccharide remodeling strategy for the synthesis of uniform chondroitin   fragments and derivatives.

Lin Yang, Xuan Xu, Shuang Li, Yi Li, Peixue   Ling,Junqiang Fang*

Carbohydrate Research.   2021,509,108442

2.104

64

Determination of the immunoglobulin G   precipitation end-point by an intelligent near infrared spectroscopy system

Chen Yu, Shuang Quan, Cui Yang, Chengliang   Zhang, Jiajin Fan, Lian Li*, Hengchang Zang*

Journal of Innovative Optical Health   Sciences. 2021,03,215007

1.77

65

Study on the pharmacokinetic profiles of   three ingredients in Qilong capsules and their potential interactions in rats   by LC-MS/MS

Ruichen Liu, Huiliang Liang, Zhen Li, Hengchang Zang*

Journal   of Chromatographic Science. 2021,1-8

1.618

66

真菌组蛋白赖氨酸甲基转移酶的研究进展

李梦雪,李亚楠,曲音波,秦玉琪*

微生物学报 2021, 61(10), 2986-2998

67

HILIC-M S /M S 法鉴别肝素和硫酸乙酰肝素

刘冬科,王凤山*

山东大学学报( 医学版)