吴选俊 教授 博士生导师  山东省泰山学者青年专家

山东省优秀青年基金获得者

山东大学齐鲁青年学者

通讯地址：山东省青岛市即墨滨海公路72号山东大学青岛校区K6-206室

办公室电话：(0532)-58631426

邮箱：xuanjun@sdu.edu.cn

教育经历

2010.9-2015.6   厦门大学 化学生物学系，理学博士，导师: 韩守法教授

2005.9-2009.7   安徽农业大学 生物技术专业，理学学士

工作经历

2019.6-今          山东大学国家糖工程技术研究中心，齐鲁青年学者/教授

2015.7-2019.5   美国密歇根州立大学化学系，博士后，导师: 黄雪飞教授

研究方向

采用多学科交叉策略，开发结构精准的糖纳米颗粒疫苗。通过整合糖化学合成、纳米组装与免疫工程技术，构建分子结构明确的新型糖抗原-载体复合物。重点突破糖表位精准修饰与定向展示技术，建立糖免疫原的理性设计范式，并利用多尺度表征优化免疫原性，最终获得高效特异的糖疫苗候选分子。

奖励与荣誉

山东省泰山学者青年专家（2023年）

福建省科学技术进步奖二等奖（2019年）

厦门市科学技术进步奖二等奖（2019年）

福建医学科技奖二等奖（2018年）

博士研究生国家奖学金（2014年）

教育部博士学术新人奖（2012年）

科研项目

1.国家自然科学基金面上项目，2024-01至2027-12，在研，主持

2.山东省泰山学者项目，2024-01至2026-12，在研，主持

3.山东省优秀青年基金，2023-01至2025-12，在研，主持

4.国家自然科学基金青年科学基金，2021-01至2023-12，已结题，主持

5.山东省自然科学基金青年基金，2021-01至2023-12，已结题，主持

6.江苏省自然科学基金青年基金，2020-07至2023-06，已结题，主持

7.山东大学微生物技术国家重点实验室开放课题基金，2020-07至2021-07，已结题，主持

8.山东大学齐鲁青年学者基金，2019-05至2024-05，已结题，主持

代表性论文（*，通讯作者）

1. Chendong Yang, Entao Li, Xiaoping Guo, Wenyu Xie, Yuanzhan Wang, Xuefei Huang, Sandra Chiu,* and Xuanjun Wu*. A Self-Assembled Nanovaccine with BA.4/5 Receptor-Binding Domain and CpG Oligodeoxynucleotides Induces Broad-Spectrum Neutralization against SARS-CoV-2 Omicron Subvariants. ACS Nano, 2025, DOI: 10.1021/acsnano.4c17269.

2. Yanan Gao, Wei Wang, Yunru Yang, Qingyu Zhao, Chendong Yang, Xiaoying Jia, Yang Liu, Minmin Zhou, Weihong Zeng, Xuefei Huang, Sandra Chiu*, Tengchuan Jin*, and Xuanjun Wu* Developing next-generation protein-based vaccines using high-affinity glycan ligand-decorated glyconanoparticles, Adv. Sci. 2023, 10, 2204598.

3. Yanan Gao, Qingyu Zhao, Huiling Dong, Min Xiao, Xuefei Huang, Xuanjun Wu*, Developing acid-responsive glyco-nanoplatform based vaccines for enhanced cytotoxic T-lymphocyte responses against cancer and SARS-CoV-2, Adv. Funct. Mater. 2021, 31, 2105059.

4. Yanan Gao, Qingyu Zhao, Min Xiao, Xuefei Huang, Xuanjun Wu*, A versatile photothermal vaccine based on acid-responsive glyco-nanoplatform for synergistic therapy of cancer, Biomaterials, 2021, 273, 120792.

5. Xuanjun Wu, J Ye, A T. DeLaitsch, Z Rashidijahanabad, S Lang, T Kakeshpour, Y Zhao, S R, P V Saavedra, V Yuzbasiyan-Gurkan, H Cao,* J Gildersleeve,* and X Huang*. Chemoenzymatic Synthesis of 9NHAc-GD2 Antigen to Overcome Hydrolytic Instability of O-Acetylated-GD2 for Anticancer Conjugate Vaccine Development, Angew.Chem.Int.Ed. 2021, 60, 24179–24188.

6. Xuanjun Wu, Z Yin, C McKay, C Pett, J Yu, M Schorlemer, T Gohl, S Sungsuwan, S Ramadan, C Baniel, Anthony, R Das, U Westerlind, M. Finn, and X Huang*. Protective epitope discovery and the design of MUC1 based vaccine for effective tumor protections in immunotolerant mice. J. Am. Chem. Soc., 2018, 140, 16596–16609.

7. Qingyu Zhao, Xuefei Huang, Xuanjun Wu*. Development of NHAcGD2/NHAcGD3 conjugates of bacteriophage MX1 virus-like particles as anticancer vaccines. RSC Adv., 2024, 14, 6246–6252.

8. Huiling Dong, Xuefei Huang, Xuanjun Wu*. Development of a novel sialic acid-conjugated camptothecin prodrug for enhanced cancer chemotherapy. Biomater. Sci., 2023, 11, 6160–6166.

9. Jiale Wang, Chendong Yang, Yanan Gao and Xuanjun Wu*. Development of superior nanotheranostic agents with indocyanine green-conjugated poly(styrene-alt-maleic acid) nanoparticles for tumor imaging and phototherapy. J. Mater. Chem. B., 2023, 11, 6560–6566.

10. Huiling Dong, Yanan Gao, Xuefei Huang, Xuanjun Wu* Synthesis of sialic acid conjugates of the clinical near-infrared dye as next-generation theranostics for cancer phototherapy, J. Mater. Chem. B., 2022, 10, 927–934.

11. Qingyu Zhao, Yanan Gao, Min Xiao, Xuefei Huang, Xuanjun Wu*, Synthesis and immunological evaluation of synthetic peptide based anti-SARS-CoV-2 vaccine candidates, Chem. Commun., 2021, 57, 1474–1477.

12. Xuanjun Wu, H McFall-Boegeman, Z Rashidijahanabad, K Liu, C Pett, J Yu, M Schorlemer, S Ramadan, S Behren, U Westerlind and X Huang, Synthesis and Immunological Evaluation of the Unnatural β-linked Mucin-1 Thomsen-Friedenreich Conjugate, Org. Biomol. Chem., 2021, 19, 2448–2455.

13. Xuanjun Wu, C McKay, C Pett, J Yu, M Schorlemer, S Ramadan, S Lang, U Westerlind, M. Finn, and X Huang*. Synthesis and immunological evaluation of disaccharide bearing MUC-1 glycopeptide conjugates with virus-like particles. ACS Chem. Biol. 2019, 14, 2176–2184.

14. Z Yin†, Xuanjun Wu†, K Kaczanowska, S Sungsuwan, Aragones, C Pett, J Yu, C Baniel, U Westerlind, M Finn, and X Huang*. Anti-tumor humoral and T cell responses by mucin-1 conjugates of bacteriophage Qb in wildtype mice. ACS Chem. Biol. 2018, 13, 1668–1676. (†, contributed equally)

15. B Lin†, Xuanjun Wu†, H Zhao, Y Tian, J Han, J Liu, S Han*. Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface. Chem. Sci., 2016, 7, 3737–3741. (†, contributed equally)

16. Xuanjun Wu, B Lin, M Yu, L Yang, J Han, S Han*. A carbohydrate-grafted nanovesicle with activatable optical and acoustic contrasts for dual modality high performance tumor imaging. Chem. Sci. 2015, 6, 2002–2009.

17. Xuanjun Wu, M Yu, B Lin, H Xing, J Han, S Han*. A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation. Chem. Sci. 2015. 6, 789–803.

18. Xuanjun Wu, Y Tian, M Yu, J Han, S Han*. A targetable acid-responsive micellar system for signal activation based high performance surgical resolution of tumors. Biomater. Sci. 2014, 2, 972–979. (IF 6.843)

19. Xuanjun Wu, Y Tian, M Yu, B Lin, J Han, S Han*. A fluorescently labelled sialic acid for high performance intraoperative tumor detection. Biomater. Sci. 2014, 2, 1120–1127.

20. Xuanjun Wu, J Shi, L Yang, J Han, S Han*. A near-infrared fluorescence dye for sensitive detection of hydrogen sulfide in serum. Bioorg Med Chem Lett. 2014, 24, 314–316.

21. Xuanjun Wu, Z Li, L Yang, J Han, S Han*. A self-referenced nanodosimeter for reaction based ratiometric imaging of hypochlorous acid in living cells. Chem. Sci. 2013, 4, 460–467.

22. Xuanjun Wu, Y Song, J Han, L Yang, S Han*. Traceless protein delivery with an efficient recyclable nanocarrier. Biomater. Sci. 2013, 1, 918–923.

23. Z Wu†, Xuanjun Wu†, Z Li, Y Yang, J Han, S Han*. Benzothiazoline based chemodosimeters for fluorogenic detection of hypochlorous acid. Bioorg Med Chem Lett 2013, 23, 4354–4357. (†, contributed equally)

24. Xuanjun Wu, S Wu, L Yang, J Han, S Han*. Cytosolic delivery of proteins mediated by aldehyde-displaying silica nanoparticles with pH-responsive characteristics. J. Mater. Chem. 2012, 22, 17121–17127.

25. Xuanjun Wu, Z Wu, Y Yang, S Han*. A highly sensitive fluorogenicchemodosimeter for rapid visual detection of phosgene. Chem. Commun. 2012, 48, 1895–1897.

26. Xuanjun Wu, Z Wu, S Han*. Chromogenic and fluorogenic detection of a nerve agent simulant with a rhodamine-deoxylactam based sensor. Chem. Commun. 2011, 47, 11468–11470.

授权与申请国家发明专利

1. 2023107800168，一种唾液酸-喜树碱前药Sia-ss-CPT及其制备方法与应用，发明人：吴选俊，董会玲

2. ZL 2022 1 1340059.6，一种基于高亲和力Siglec-1配体修饰的葡聚糖纳米疫苗及其制备方法和应用，发明人：吴选俊，高亚楠

3. ZL 2021 1 1644096.1，一种唾液酸连接吲哚菁绿Sia-ICG及其制备方法和应用，发明人：吴选俊，董会玲

4. ZL201510474118.2，一种抗原连接的唾液酸及其应用，发明人：韩守法，刘剑，吴选俊, 林碧娟

5. ZL201410069518.0，一种荧光素标记的唾液酸试剂及其制备方法与应用，发明人：韩守法，吴选俊, 田云鹏

6. ZL201410015353.9，罗丹明功能化的聚(苯乙烯-交替半乳糖基马来酸)及其合成方法与应用，发明人：韩守法，吴选俊

7. ZL 2013 1 0287924. X，磷酸吡哆醛功能化磷酸钙纳米颗粒及其制备方法与应用，发明人：韩守法，吴选俊

指导研究生获奖情况

指导博士生获第二届“惠永正糖科学奖·优秀学业奖”、山东大学校长奖、博士研究生国家奖学金等奖项；指导多名硕士生获硕士研究生国家奖学金。

本课题组在生物化学与分子生物学和生物医药专业均招收硕士、博士研究生。欢迎有兴趣的考生报考！