吴选俊 教授 博士生导师 山东省优秀青年基金获得者
山东大学齐鲁青年学者
通讯地址: 山东省青岛市即墨滨海公路72号山东大学青岛校区K6-206室
办公室电话：(0532)-58631426
邮箱: xuanjun@sdu.edu.cn
教育经历
2010.9-2015.6 厦门大学 化学生物学系，理学博士，导师: 韩守法教授
2005.9-2009.7 安徽农业大学 生物技术专业，理学学士
工作经历
2019.6-今 山东大学国家糖工程技术研究中心，齐鲁青年学者/教授
2015.7-2019.5 美国密歇根州立大学化学系，博士后，导师: 黄雪飞教授
研究方向
1. 制备强效免疫载体；化学酶法合成新型糖类抗原；基于强效免疫载体和新型糖类抗原研制新一代糖疫苗。
2. 分离、纯化生物来源多糖；糖链结构的解析；基于多糖研制新一代糖纳米疫苗。
奖励与荣誉
福建医学科技奖二等奖（2018年）、厦门市科学技术进步奖二等奖（2019年）、福建省科学技术进步奖二等奖（2019年）
科研项目
1. 山东省优秀青年基金，2023-01至2026-12，在研，主持
2. 国家自然科学基金青年科学基金，2021-01至2023-12，在研，主持
3. 山东省自然科学基金青年基金，2021-01至2023-12，在研，主持
4. 江苏省自然科学基金青年基金，2020-07至2023-06，在研，主持
5. 山东大学微生物技术国家重点实验室开放课题基金，2020-07至2021-07，结题，主持
6. 山东大学齐鲁青年学者基金，2019-05至2024-05，在研，主持
7. 美国国家癌症研究所，研究计划基金，2018-01至2022-12，在研，参加（第一）
代表性论文
1. Yanan Gao1, Wei Wang1, Yunru Yang, Qingyu Zhao, Chendong Yang, Xiaoying Jia, Yang Liu, Minmin Zhou, Weihong Zeng, Xuefei Huang, Sandra Chiu*, Tengchuan Jin*, and Xuanjun Wu*. Developing next-generation protein-based vaccines using high-affinity glycan ligand-decorated glyconanoparticles. Advanced Science 2022, in press. (IF 17.521)
2. Xuanjun Wu, J Ye, A T. DeLaitsch, Z Rashidijahanabad, S Lang, T Kakeshpour, Y Zhao, S R, P V Saavedra, V Yuzbasiyan-Gurkan, H Cao,* J Gildersleeve,* and X Huang*. Chemoenzymatic Synthesis of 9NHAc-GD2 Antigen to Overcome Hydrolytic Instability of O-Acetylated-GD2 for Anticancer Conjugate Vaccine Development. Angew.Chem.Int.Ed. 2021, 60, 24179–24188 (IF 16.823)
3. Y Gao, Q Zhao, H Dong, M Xiao, X Huang, Xuanjun Wu*. Developing acid-responsive glyco-nanoplatform based vaccines for enhanced cytotoxic T-lymphocyte responses against cancer and SARS-CoV-2. Adv. Funct. Mater. 2021, 31, 2105059. (IF 19.924)
4. Y Gao, Q Zhao, M Xiao, X Huang, Xuanjun Wu*, A versatile photothermal vaccine based on acid-responsive glyco-nanoplatform for synergistic therapy of cancer. Biomaterials, 2021, 273, 120792. (IF 15.304)
5. Xuanjun Wu, Z Yin, C McKay, C Pett, J Yu, M Schorlemer, T Gohl, S Sungsuwan, S Ramadan, C Baniel, Anthony, R Das, U Westerlind, M. Finn, and X Huang*. Protective epitope discovery and the design of MUC1 based vaccine for effective tumor protections in immunotolerant mice. J. Am. Chem. Soc. 2018, 140, 16596–16609. (IF 16.383)
6. B Lin1, Xuanjun Wu1, H Zhao, Y Tian, J Han, J Liu, S Han*. Redirecting immunity via covalently incorporated immunogenic sialic acid on the tumor cell surface. Chem. Sci. 2016, 7, 3737–3741. (1, contributed equally) (IF 9.969)
7. Xuanjun Wu, B Lin, M Yu, L Yang, J Han, S Han*. A carbohydrate-grafted nanovesicle with activatable optical and acoustic contrasts for dual modality high performance tumor imaging. Chem. Sci. 2015, 6, 2002–2009. (IF 9.969)
8. Xuanjun Wu, M Yu, B Lin, H Xing, J Han, S Han*. A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation. Chem. Sci. 2015. 6, 789–803. (IF 9.969)
9. Xuanjun Wu, Z Li, L Yang, J Han, S Han*. A self-referenced nanodosimeter for reaction based ratiometric imaging of hypochlorous acid in living cells. Chem. Sci. 2013, 4, 460–467. (IF 9.969)
10. Huiling Dong, Yanan Gao, Xuefei Huang, Xuanjun Wu*. Synthesis of sialic acid conjugates of the clinical near-infrared dye as next-generation theranostics for cancer phototherapy. J. Mater. Chem. B., 2022, 10, 927–934. (IF 7.571)
11. Q Zhao, Y Gao, M Xiao, X Huang, Xuanjun Wu*, Synthesis and immunological evaluation of synthetic peptide based anti-SARS-CoV-2 vaccine candidates, Chem. Commun., 2021, 57, 1474–1477. (IF 6.222)
12. Xuanjun Wu, H McFall-Boegeman, Z Rashidijahanabad, K Liu, C Pett, J Yu, M Schorlemer, S Ramadan, S Behren, U Westerlind and X Huang, Synthesis and Immunological Evaluation of the Unnatural β-linked Mucin-1 Thomsen-Friedenreich Conjugate, Org. Biomol. Chem., 2021, 19, 2448–2455. (IF 3.876)
13. Xuanjun Wu, C McKay, C Pett, J Yu, M Schorlemer, S Ramadan, S Lang, U Westerlind, M. Finn, and X Huang*. Synthesis and immunological evaluation of disaccharide bearing MUC-1 glycopeptide conjugates with virus-like particles. ACS Chem. Biol. 2019, 14, 2176–2184. (IF 5.100)
14. Z Yin1, Xuanjun Wu1, K Kaczanowska, S Sungsuwan, Aragones, C Pett, J Yu, C Baniel, U Westerlind, M Finn, and X Huang*. Anti-tumor humoral and T cell responses by mucin-1 conjugates of bacteriophage Qb in wildtype mice. ACS Chem. Biol. 2018, 13, 1668–1676. (1, contributed equally) (IF 5.100)
15. Xuanjun Wu, Y Tian, M Yu, J Han, S Han*. A targetable acid-responsive micellar system for signal activation based high performance surgical resolution of tumors. Biomater. Sci. 2014, 2, 972–979. (IF 6.843)
16. Xuanjun Wu, Y Tian, M Yu, B Lin, J Han, S Han*. A fluorescently labelled sialic acid for high performance intraoperative tumor detection. Biomater. Sci. 2014, 2, 1120–1127. (IF 6.843)
17. Xuanjun Wu, J Shi, L Yang, J Han, S Han*. A near-infrared fluorescence dye for sensitive detection of hydrogen sulfide in serum. Bioorg Med Chem Lett. 2014, 24, 314–316. (IF 2.448)
18. Xuanjun Wu, Y Song, J Han, L Yang, S Han*. Traceless protein delivery with an efficient recyclable nanocarrier. Biomater. Sci. 2013, 1, 918–923. (IF 6.843)
19. Z Wu1, Xuanjun Wu1, Z Li, Y Yang, J Han, S Han*. Benzothiazoline based chemodosimeters for fluorogenic detection of hypochlorous acid. Bioorg Med Chem Lett 2013, 23, 4354–4357. (1, contributed equally) (IF 2.448)
20. Xuanjun Wu, S Wu, L Yang, J Han, S Han*. Cytosolic delivery of proteins mediated by aldehyde-displaying silica nanoparticles with pH-responsive characteristics. J. Mater. Chem. 2012, 22, 17121–17127. (IF 6.626)
21. Xuanjun Wu, Z Wu, Y Yang, S Han*. A highly sensitive fluorogenicchemodosimeter for rapid visual detection of phosgene. Chem. Commun. 2012, 48, 1895–1897. (IF 6.222)
22. Xuanjun Wu, Z Wu, S Han*. Chromogenic and fluorogenic detection of a nerve agent simulant with a rhodamine-deoxylactam based sensor. Chem. Commun. 2011, 47, 11468–11470. (IF 6.222)
获得与申请国家发明专利
1. ZL 2013 1 0287924. X，磷酸吡哆醛功能化磷酸钙纳米颗粒及其制备方法与应用，发明人：韩守法，吴选俊
2. ZL201410015353.9，罗丹明功能化的聚(苯乙烯-交替半乳糖基马来酸)及其合成方法与应用，发明人：韩守法，吴选俊
3. ZL201410069518.0，一种荧光素标记的唾液酸试剂及其制备方法与应用，发明人：韩守法，吴选俊, 田云鹏
4. ZL201510474118.2，一种抗原连接的唾液酸及其应用，发明人：韩守法，刘剑，吴选俊, 林碧娟
5. 202111644096.1，一种唾液酸连接吲哚菁绿Sia-ICG及其制备方法和应用，发明人：吴选俊，董会玲
指导研究生获奖情况
指导博士生获山东大学校长奖（2021年）、博士研究生国家奖学金（2021年）、青岛市千名优秀大学生（2021年）和第三届糖复合物研究优秀论文三等奖（2022年）；指导硕士生获硕士研究生国家奖学金（2021年和2022年）。
本课题组在生物化学与分子生物学和生物医药专业均招收硕士、博士研究生。欢迎有兴趣的考生报考！
