谭海宁 博士
教授，博士生导师，山东省泰山产业领军人才
国家糖工程技术研究中心副主任
青岛市即墨滨海路72号K6-216室
济南市文化西路44号药学院科研楼302室
E-mail: hainingtan@sdu.edu.cn
学习和工作经历
2009/07至今，山东大学，国家糖工程技术研究中心，任教
2004/09至2009/07，山东大学，药学院，博士研究生/博士
2000/09至2004/07，山东大学，药学院，本科/学士
研究方向
1. 蛋白质、多肽药物的化学修饰。
2. 抗肿瘤药物及递送系统研究。
3. 糖类药物研究。
4. 医养健康产品研发。
承担项目
先后主持国家级和省部级课题十余项，横向课题数项，作为课题副组长完成民口和军口国家重大新药创制计划各1项；在Small, Journal of Controlled Release和Carbohydrate Polymers等学术期刊上发表SCI论文30余篇；获得发明专利4项；参编著作4部；Small、Acs Nano和Carbohydrate Polymers等学术期刊审稿人；Current Phamaceutical Biotechnology等杂志客座编辑；中国生物化学与分子生物学会工业生物化学与分子生物学会分会理事，中国药理学会海洋药物药理专业委员会委员。
近期代表性论文
1. Feng Sun, Huiwen Hou, Yan Li, Wen Tang, Jie Wang, Lu Lu, Jiaai Fu, Zengmei Liu, Didi Gao, Feiyan Zhao, Xinqing Gao, Peixue Ling, Fengshan Wang, and Haining Tan*. Glycol-split Heparin-Linked Prodrug Nanoparticles Target the Mitochondrion Apparatus for Cancer Metastasis Treatment, Small, 2023, 2206491.
2. Yan Li, Huiwen Hou, Zengmei Liu, Wen Tang, Jie Wang, Lu Lu, Jiaai Fu, Didi Gao, Feiyan Zhao, XinQing Gao, Peixue Ling, Fengshan Wang, Feng Sun, and Haining Tan*. CD44 targeting nanodrug based on chondroitin sulfate for melanoma therapy by inducing mitochondrial apoptosis pathways. Carbohydrate Polymers, 2023, 320, 121255.
3. Feng Sun, Yang Yu, Zhifang Yang, Zhendong Wang, Yan Li, Fengshan Wang, and Haining Tan*. Hyaluronic acid-endostatin2-alft1 (HA-ES2-AF) nanoparticle-like conjugate for the target treatment of diseases. Journal of Controlled Release, 288,1-13, 2018.
4. Feng Sun, Zhendong Wang, Zhifang Yang, Yan Li, Huifei Cui, Chunhui Liu, DezongGao, Fengshan Wang, and Haining Tan*. Characterization, bioactivity and pharmacokinetic study of a novel carbohydrate-peptide polymer: glycol-split heparin-endostatin2 (GSHP-ES2). Carbohydrate Polymers, 207, 79-90, 2019.
5. Zhendong Wang, Yan Li, Liang Xing, Feng Sun, Zhifang Yang, Fengshan Wang, and Haining Tan*. Effects of the anti-angiogenic carbohydrate-peptide conjugate, chitooligosaccharide-ES2 on endothelial cells and tumor-bearing mice. Carbohydrate Polymers, 208, 302-313, 2019.
6. Yang Yu, Feng Sun, Congcong Zhang, Zhendong Wang, Jinfeng Liu, and Haining Tan*. Study on glyco-modification of endostatin-derived synthetic peptide endostatin2 (ES2) by soluble chitooligosaccharide. Carbohydrate Polymers, 154, 204-213, 2016.
7. Zhongying Gong, Baolong Zhou, Xiaoying Liu, Juanjuan Cao, Zexin Hong, Jingye Wang, Xirui Sun, Xiaomeng Yuan, Haining Tan*, Hongjie Ji, and Jingkun Bai* Enzyme-Induced Transformable Peptide Nanocarriers with Enhanced Drug Permeability and Retention to Improve Tumor Nanotherapy Efficacy. ACS Appl Mater Interfaces, 13, 47, 55
